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MOLEonline 2.0：生物大分子通道的交互式网络分析。

MOLEonline 2.0: interactive web-based analysis of biomacromolecular channels.

机构信息

Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University Olomouc, tr. 17. listopadu 12, 771 46 Olomouc, Czech Republic.

出版信息

Nucleic Acids Res. 2012 Jul;40(Web Server issue):W222-7. doi: 10.1093/nar/gks363. Epub 2012 May 2.

DOI:10.1093/nar/gks363
PMID:22553366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3394309/
Abstract

Biomolecular channels play important roles in many biological systems, e.g. enzymes, ribosomes and ion channels. This article introduces a web-based interactive MOLEonline 2.0 application for the analysis of access/egress paths to interior molecular voids. MOLEonline 2.0 enables platform-independent, easy-to-use and interactive analyses of (bio)macromolecular channels, tunnels and pores. Results are presented in a clear manner, making their interpretation easy. For each channel, MOLEonline displays a 3D graphical representation of the channel, its profile accompanied by a list of lining residues and also its basic physicochemical properties. The users can tune advanced parameters when performing a channel search to direct the search according to their needs. The MOLEonline 2.0 application is freely available via the Internet at http://ncbr.muni.cz/mole or http://mole.upol.cz.

摘要

生物分子通道在许多生物系统中发挥着重要作用，例如酶、核糖体和离子通道。本文介绍了一个基于网络的交互式 MOLEonline 2.0 应用程序，用于分析进入/离开内部分子空隙的通道/出口路径。MOLEonline 2.0 支持平台独立、易于使用和交互式的（生物）大分子通道、隧道和孔分析。结果以清晰的方式呈现，易于解释。对于每个通道，MOLEonline 都会显示通道的 3D 图形表示，其轮廓伴随着一系列衬里残基的列表，以及其基本的物理化学性质。用户可以在执行通道搜索时调整高级参数，根据需要指导搜索。MOLEonline 2.0 应用程序可通过 Internet 在 http://ncbr.muni.cz/mole 或 http://mole.upol.cz 上免费获得。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fabb/3394309/8c413909c85d/gks363f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fabb/3394309/073669c2e07f/gks363f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fabb/3394309/831db5341883/gks363f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fabb/3394309/8c413909c85d/gks363f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fabb/3394309/073669c2e07f/gks363f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fabb/3394309/831db5341883/gks363f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fabb/3394309/8c413909c85d/gks363f3.jpg

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