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本文引用的文献

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Role of vascular endothelial growth factor in ocular angiogenesis.血管内皮生长因子在眼部血管生成中的作用。
Ophthalmol Clin North Am. 2006 Sep;19(3):335-44. doi: 10.1016/j.ohc.2006.05.005.
2
Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo.视网膜血管内皮生长因子诱导细胞间黏附分子-1和内皮型一氧化氮合酶表达，并在体内引发早期糖尿病视网膜白细胞黏附。
Am J Pathol. 2002 Feb;160(2):501-9. doi: 10.1016/S0002-9440(10)64869-9.
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Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy.糖尿病性玻璃体视网膜病变患者玻璃体液和血清中的炎性细胞因子
J Diabetes Complications. 2001 Sep-Oct;15(5):257-9. doi: 10.1016/s1056-8727(01)00155-6.
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Anti-proliferative effect of ginseng saponins on human prostate cancer cell line.
Life Sci. 2000 Aug 4;67(11):1297-306. doi: 10.1016/s0024-3205(00)00720-7.
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Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng.红参中的皂苷、人参皂苷-Rb2、20（R）-和20（S）-人参皂苷-Rg3对小鼠肿瘤转移的抑制作用
Biol Pharm Bull. 1995 Sep;18(9):1197-202. doi: 10.1248/bpb.18.1197.
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Inhibition of in vitro tumor cell invasion by ginsenoside Rg3.人参皂苷Rg3对体外肿瘤细胞侵袭的抑制作用。
Jpn J Cancer Res. 1996 Apr;87(4):357-62. doi: 10.1111/j.1349-7006.1996.tb00230.x.

人参皂苷-Rg3对糖尿病大鼠视网膜中血管内皮生长因子（VEGF）和肿瘤坏死因子-α（TNF-α）表达的影响。

Effect of ginsenoside-Rg3 on the expression of VEGF and TNF-α in retina with diabetic rats.

作者信息

Sun Hong-Quan, Zhou Zhan-Yu

机构信息

Department of Ophthalmology, the Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong Province, China.

出版信息

Int J Ophthalmol. 2010;3(3):220-3. doi: 10.3980/j.issn.2222-3959.2010.03.09. Epub 2010 Sep 18.

DOI:10.3980/j.issn.2222-3959.2010.03.09
PMID:22553558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3340625/
Abstract

AIM

To investigate the effect of ginsenoside-Rg3 on the expression of vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) in retina with diabetic rats and its roles in preventing neovascularization in diabetes.

METHODS

Sixty male Wistar rats were divided into 3 groups randomly: negative control group, diabetic control group and ginsenoside-Rg3 treatment group (5mg/kg, 0.2mg/mL) followed by establishing diabetic model. The expression of VEGF and TNF-α were measured after 8 weeks.

RESULTS

There were significant differences among negative control group, diabetic control group and ginsenoside-Rg3 treatment group in the expression of VEGF and TNF-α (F=129.363, 211.992; all the P<0.01). VEGF and TNF-α expression were significantly higher in diabetic control group and ginsenoside-Rg3 treatment group than that in negative control group (P<0.01), with a significant reduction in ginsenoside-Rg3 treatment group than that in diabetic control group (P<0.01).

CONCLUSION

Ginsenoside-Rg3 can down-regulate the expression of VEGF and TNF-α in retina, which may interfere in the development of diabetic retinopathy.

摘要

目的

探讨人参皂苷-Rg3对糖尿病大鼠视网膜血管内皮生长因子（VEGF）和肿瘤坏死因子-α（TNF-α）表达的影响及其在预防糖尿病新生血管形成中的作用。

方法

60只雄性Wistar大鼠随机分为3组：阴性对照组、糖尿病对照组和人参皂苷-Rg3治疗组（5mg/kg，0.2mg/mL），随后建立糖尿病模型。8周后检测VEGF和TNF-α的表达。

结果

阴性对照组、糖尿病对照组和人参皂苷-Rg3治疗组之间VEGF和TNF-α的表达有显著差异（F=129.363，211.992；均P<0.01）。糖尿病对照组和人参皂苷-Rg3治疗组中VEGF和TNF-α的表达显著高于阴性对照组（P<0.01），人参皂苷-Rg3治疗组较糖尿病对照组显著降低（P<0.01）。

结论

人参皂苷-Rg3可下调视网膜中VEGF和TNF-α的表达，这可能会干扰糖尿病视网膜病变的发展。