Yuan Jia-Ying, Zhang Jian-Hua, Tang Chong, Zhu Hong, Xie Hua, Gao Shuan-Jie
Department of Ultrasonography Directly under Hospital of Military Area of Henan, Zhengzhou 450003, Henan Province,China.
Int J Ophthalmol. 2011;4(5):537-42. doi: 10.3980/j.issn.2222-3959.2011.05.15. Epub 2011 Oct 18.
To analyze the application of microbubble contrast technology in the treatment of ophthalmic diseases, mainly analyzing its advantages and existing problems.
A total of 30 representative literatures about the application of ultrasound contrast agent in gene targeted therapy at home and abroad were collected, and focusing on sorting out the literature reporting the treatment of ophthalmic diseases with microbubble contrast technology in recent years, then recalling its advantages and problems, finally making reasonable assessment on existing problems and proposing possible solutions to the problems.
DUE TO ITS UNIQUE SAFETY AND EFFICACY, THE TREATMENT OF OPHTHALMIC DISEASES WITH MICROBUBBLE CONTRAST TECHNOLOGY HAS INCREASINGLY DRAWN THE ATTENTION OF CLINICIANS, BUT TWO RELEVANT ISSUES SHOULD BE CONSIDERED: first, the nature of contrast agent and the choice of corresponding ultrasound parameters; second, relative incidence of tissue bleeding, intravascular hemolysis, moderate or severe allergy as well as other side effects.
Microbubble may become the carrier of targeted therapy, and as a kind of new non-invasive delivery system, the ultrasound contrast agent has broad application prospects, but its application in ophthalmic research is still in its initial stage and the safety of contrast-enhanced ultrasound still needs further study.
分析微泡造影技术在眼科疾病治疗中的应用，主要分析其优势及存在的问题。
收集国内外30篇关于超声造影剂在基因靶向治疗中应用的代表性文献，重点梳理近年来报道用微泡造影技术治疗眼科疾病的文献，回顾其优势与问题，最后对存在的问题进行合理评估并提出可能的解决办法。
由于其独特的安全性和有效性，微泡造影技术治疗眼科疾病越来越受到临床医生的关注，但应考虑两个相关问题：一是造影剂的性质及相应超声参数的选择；二是组织出血、血管内溶血、中度或重度过敏以及其他副作用的相对发生率。
微泡可能成为靶向治疗的载体，超声造影剂作为一种新型非侵入性给药系统具有广阔的应用前景，但其在眼科研究中的应用仍处于初始阶段，超声造影增强的安全性仍需进一步研究。
