Laboratory of Nanotoxicology Project, Nagoya City University, 3-1 Tanabedohri, Mizuho-ku, Nagoya 467-8603, Japan.
Biochem Cell Biol. 2012 Jun;90(3):279-306. doi: 10.1139/o2012-013. Epub 2012 May 3.
Lactoferrin is a major component of biologically important mucosal fluids and of the specific granules of neutrophils. Understanding its biological function is essential for understanding neutrophil- and mucosal-mediated immunity. In this review, we reevaluate the in vivo functions of human lactoferrin (hLF) emphasizing in vivo studies and in vitro studies performed in biologically relevant fluids. We discuss the evidence in the literature that supports (or does not support) proposed roles for hLF in mucosal immunity and in neutrophil function. We argue that the current literature supports a microbiostatic role, but not a microbicidal role, for hLF in vivo. The literature also supports a role for hLF in inhibiting colonization and infection of epithelial surfaces by microorganisms and in protecting tissues from neutrophil-mediated damage. Using this information, we briefly discuss hLF in the context of the complex biological fluids in which it is found.
乳铁蛋白是生物重要黏膜液和中性粒细胞特异性颗粒的主要成分。了解其生物学功能对于理解中性粒细胞和黏膜介导的免疫至关重要。在这篇综述中，我们重新评估了人乳铁蛋白（hLF）的体内功能，强调了体内研究和在生物学相关液体内进行的体外研究。我们讨论了文献中的证据，这些证据支持（或不支持）hLF 在黏膜免疫和中性粒细胞功能中提出的作用。我们认为，目前的文献支持 hLF 在体内具有抑菌作用，但没有杀菌作用。文献还支持 hLF 在抑制微生物对上皮表面的定植和感染以及保护组织免受中性粒细胞介导的损伤方面发挥作用。利用这些信息，我们简要地讨论了 hLF 在其存在的复杂生物液体内的情况。
