Wang Yuchen, Ding Yi, Jiang Xiaodan, Yang Jiarui, Li Xuemin
Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Department of Ophthalmology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Capital Medical College Attached Beijing Shijitan Hospital, No. 10, Xi Toutiao, Youanmen Wai Street, Beijing 100069, China.
J Clin Med. 2022 Jul 12;11(14):4019. doi: 10.3390/jcm11144019.
(1) Background: Dry eye is a multifactorial disease of the ocular surface, the incidence of which has been increasing sharply. The pathogenesis of dry eye, especially in terms of the bacterial flora, has drawn great attention. Additionally, the potential treatment methods need to be explored. (2) Methods: We reviewed more than 100 studies and summarized them briefly in a review. (3) Results: We summarized the bacterial communities found on the ocular surface in the general population and patients with dry eye and found a relationship between dry eye and antibiotic therapy. We identified the possible mechanisms of bacteria in the development of dry eye by discussing factors such as the destruction of the antibacterial barrier, infectious diseases, microbiome homeostasis, inflammatory factors on the ocular surface and vitamin deficiency. (4) Conclusion: We systematically reviewed the recent studies to summarize the bacterial differences between patients with dry eye and the general population and brought up several possible mechanisms and possible treatment targets.
（1）背景：干眼症是一种眼表多因素疾病，其发病率一直在急剧上升。干眼症的发病机制，尤其是在细菌菌群方面，已引起极大关注。此外，还需要探索潜在的治疗方法。（2）方法：我们查阅了100多项研究，并在一篇综述中对其进行了简要总结。（3）结果：我们总结了普通人群和干眼症患者眼表发现的细菌群落，并发现了干眼症与抗生素治疗之间的关系。通过讨论抗菌屏障破坏、传染病、微生物群稳态、眼表炎症因子和维生素缺乏等因素，我们确定了细菌在干眼症发生发展中的可能机制。（4）结论：我们系统地回顾了近期研究，以总结干眼症患者与普通人群之间的细菌差异，并提出了几种可能的机制和可能的治疗靶点。
