Metabolic Bone Diseases Unit, Department and Clinic of Internal Diseases, Diabetology and Nephrology, Medical University of Silesia in Katowice, ul 3-Maja 13/15, 41-800 Zabrze, Poland.
Obes Surg. 2012 Jul;22(7):1068-76. doi: 10.1007/s11695-012-0654-8.
The aim of the study was to establish longitudinal bone changes in obese women after laparoscopic sleeve gastrectomy (LSG).
Twenty-nine women at baseline mean age of 40.41 ± 9.26 years and with mean body mass index (BMI) of 43.07 ± 4.99 kg/m(2) were included in a 6-month study. Skeletal status at hip [femoral neck (FN) and total hip (TH)] and spine was assessed at baseline, as well as in 3 and 6 months after surgery. Body size was measured at baseline and follow-up (weight, height, BMI, and waist).
Baseline body weight was 117.5 ± 18.4 kg. The mean body weight and BMI decreased by 17.9 % during the first 3 months after surgery to obtain 28.4 % after 6 months. At 6 months, BMD decreased significantly for spine by 1.24 %, FN 6.99 %, and TH 5.18 %. The changes after 3 months in individual subjects showed that, in the majority of subjects, FN and TH BMD decreased significantly (in 52 % and 69 % of subjects, respectively), and in 24 % loss of BMD was found at the spine. After 6 months, the corresponding, significant decreases in individual subjects were found in 72 %, 86 %, and 38 % of woman, respectively. Those with a significant loss of FN BMD tended to lose more weight (30 ± 9.47 versus 23.25 ± 6.08 kg, p = 0.061) than others; women with a significant decrease of FN BMD lost more weight than those with no such decrease (30.43 ± 8.07 versus 15 ± 1.91 kg).
LSG proved efficient for body weight reduction, however, with a parallel decline in bone mineral density.
本研究旨在探讨腹腔镜胃袖状切除术（LSG）后肥胖女性的纵向骨骼变化。
共纳入 29 名基线时平均年龄为 40.41±9.26 岁、平均体重指数（BMI）为 43.07±4.99kg/m2 的女性，随访 6 个月。基线时及术后 3、6 个月时评估髋部[股骨颈（FN）和全髋（TH）]和脊柱的骨骼状况。在基线和随访时测量身体大小（体重、身高、BMI 和腰围）。
基线时体重为 117.5±18.4kg。手术前 3 个月内体重和 BMI 平均下降 17.9%，术后 6 个月时下降 28.4%。术后 6 个月，脊柱 BMD 显著下降 1.24%，FN 下降 6.99%，TH 下降 5.18%。术后 3 个月时，多数患者 FN 和 TH 的 BMD 显著下降（分别占 52%和 69%），24%的患者脊柱 BMD 丢失。术后 6 个月，分别有 72%、86%和 38%的患者出现显著下降。FN BMD 显著下降的患者体重下降幅度更大（30±9.47 与 23.25±6.08kg，p=0.061），FN BMD 下降的患者体重下降幅度大于未下降的患者（30.43±8.07 与 15±1.91kg）。
LSG 能有效减轻体重，但同时会导致骨密度下降。
