Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, PR China.
Chembiochem. 2012 May 29;13(8):1097-9. doi: 10.1002/cbic.201200196. Epub 2012 May 3.
Unusually versatile: While the β-carbon thioether linkage in lantibiotics has long been appreciated and is relatively well characterized, a recent publication shows that the unusual sulfur-to-α-carbon thioether crosslinks in subtilosin A are produced by a radical SAM enzyme, AlbA, that contains two [4 Fe-4 S] clusters, thus highlighting the versatility of post-translational modifications in natural product biosynthesis.
虽然林可酰胺类抗生素中的β-碳硫醚键早已被人们所认识，并且得到了相对较好的描述，但最近的一篇论文表明，枯草菌素 A 中不寻常的硫到α-碳硫醚交联是由一种包含两个 [4Fe-4S] 簇的自由基 SAM 酶 AlbA 产生的，这突出了翻译后修饰在天然产物生物合成中的通用性。
