Małecka-Panas E, Rogoziński R, Torzecka W, Krysiak G, Kozłowska A
Kliniki Chorób Przewodu Pokarmowego i Przemiany Materii IMW AM w Lodzi.
Pol Tyg Lek. 1990;45(19-20):370-2.
The study aimed at evaluating an incidence of diabetes mellitus and carbohydrate tolerance disorders as well as insulinemia in patients with the history of the acute pancreatitis. Baseline glycemia was determined in 50 patients with a history of the acute pancreatitis and in 15 healthy individuals (aged between 18 and 65 years). Blood sugar was then determined 30, 60, 90 and 180 minutes following loading with 75 g of glucose. Fasting insulinemia and that following loading with 75 g glucose were determined at the same time period. Diabetes mellitus was diagnosed in 6 patients (12%) whereas carbohydrate tolerance in 4 patients (8%). A decrease in insulin response to carbohydrates was noted in 36 patients (72%) with a history of the acute pancreatitis in comparison with the control group. The obtained results suggest that the acute pancreatitis significantly decreases endocrine functioning of the pancreas. Therefore, metabolism of carbohydrates should be checked particularly in the individuals with a history of the acute pancreatitis without the symptoms of both diabetes mellitus and sugar tolerance disorders but with the signs of decreased insulin response to carbohydrates.
该研究旨在评估急性胰腺炎病史患者中糖尿病、碳水化合物耐量障碍以及胰岛素血症的发生率。对50例有急性胰腺炎病史的患者和15名健康个体（年龄在18至65岁之间）测定基础血糖。随后在给予75克葡萄糖负荷后30、60、90和180分钟测定血糖。在同一时间段测定空腹胰岛素血症以及给予75克葡萄糖负荷后的胰岛素血症。6例患者（12%）被诊断为糖尿病，4例患者（8%）存在碳水化合物耐量异常。与对照组相比，36例（72%）有急性胰腺炎病史的患者对碳水化合物的胰岛素反应降低。所得结果表明，急性胰腺炎显著降低胰腺的内分泌功能。因此，对于有急性胰腺炎病史、无糖尿病和糖耐量异常症状但有碳水化合物胰岛素反应降低迹象的个体，尤其应检查碳水化合物代谢情况。
