Kavimani S, Ilango R, Vertichelvan T
Department of Pharmacology, Periyar College of pharmaceutical sciences, Trichy - 21, Tamil Nadu, India.
Anc Sci Life. 1998 Apr;17(4):300-4.
Volatile oil of Psidium guajava leaves obtained by steam distillation was given orally to study its effects on the exudation and proliferative phases of the inflammatory reaction, using technique of carragenin induced paw edema and cotton pellets in male albino rats. The anti inflammatory activity as compared with ketorolac tromethamine. In carragenin induced edemas,. 0.8ml/kg of the volatile oil ad anti-inflammatory activity as that of ketorolac tromethamine. The oil was also found to be potent in cotton pellet granuom studies. Preliminary investigation revealed that the volatile oil fraction consist sesqueterpene which may be responsible for its anti inflammatory activity.
通过蒸汽蒸馏获得的番石榴叶挥发油经口服给药，利用角叉菜胶诱导雄性白化大鼠爪部水肿和棉球肉芽肿的技术，研究其对炎症反应渗出期和增殖期的影响。与酮咯酸氨丁三醇相比，其抗炎活性。在角叉菜胶诱导的水肿中，0.8ml/kg的挥发油具有与酮咯酸氨丁三醇相同的抗炎活性。该油在棉球肉芽肿研究中也显示出强效。初步研究表明，挥发油部分含有倍半萜烯，这可能是其具有抗炎活性的原因。
