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印楝籽油(印楝)对雄性大鼠和兔子的抗雄激素特性

'Antiandrogenic properties of neem seed oil (azadirachta indica) in male rat and rabbi'.

作者信息

Sharma J D, Jha R K, Gupta I, Jain P, Dixit V P

机构信息

Reproductive Physiology Unit, Department of Zooloogy, University of Rajasthan, Jaipur - 302 004, India.

出版信息

Anc Sci Life. 1987 Jul;7(1):30-8.

Abstract

Azadirachta indica (Neem) seed oil brings about a significant diminution in spermatozoan motility and density. It leads to reduction of fertility rate in rats and rabbits. The body weight of the animals remain unaffected but the weights of reproductive oranges declined. Reduction of cauda epididymal protein, sialic acid, acid phosphatase and seminal vesicular fructose concentration in rats and rabbits could bedue to antiandrogenic action of the seed oil as confirmed with the help of bioassay techniques. Histopathology of testis revealed arrest of spermatogenesis and sever degenerative changes in the cauda epididymis.

摘要

印楝(楝树)籽油会导致精子活力和密度显著降低。它会使大鼠和兔子的生育率下降。动物的体重未受影响,但生殖器官的重量有所下降。大鼠和兔子附睾尾部蛋白质、唾液酸、酸性磷酸酶以及精囊果糖浓度的降低,可能归因于该籽油的抗雄激素作用,这已通过生物测定技术得到证实。睾丸组织病理学显示精子发生停滞,附睾尾部出现严重退行性变化。

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