Dutta Samrat, Dasgupta Chandan, Choudhury Kakoli
Department of Radiotherapy, Medical College, Kolkata, West Bengal, India.
Indian J Med Paediatr Oncol. 2011 Jul;32(3):171-3. doi: 10.4103/0971-5851.92823.
Peripheral primitive neuroectodermal tumor (PNET) of the female genital tract, particularly those in the vaginal and paravaginal region, are extremely rare. A 36-year-old woman presented with clinical features similar to that of a case of cervical fibroid. It was only after surgery that the histopathology suggested it to be a malignant round cell tumour and was CD99 positive. She underwent adjuvant chemotherapy with the Ifosfamide and Etoposide alternating with Vincristine, Doxorubicin, and Cyclophosphamide regime and radical radiotherapy. She is disease free at 12 months of follow-up. The importance of immunostaining and adequate histopathology report lies in the fact that the correct diagnosis thus achieved enabled us to manage a rare case of paravaginal PNET with a multimodality approach.
女性生殖道外周原始神经外胚层肿瘤（PNET），尤其是阴道和阴道旁区域的此类肿瘤极为罕见。一名36岁女性的临床表现与宫颈肌瘤病例相似。直到手术后，组织病理学检查才提示其为恶性圆形细胞瘤且CD99呈阳性。她接受了异环磷酰胺和依托泊苷交替联合长春新碱、多柔比星及环磷酰胺方案的辅助化疗以及根治性放疗。随访12个月时她无疾病复发。免疫染色及充分的组织病理学报告的重要性在于，由此获得的正确诊断使我们能够采用多模式方法处理一例罕见的阴道旁PNET病例。
