National Center for Radiation Research in Oncology, Technische Universität Dresden, Fetscherstr, Dresden, Germany.
Med Phys. 2012 May;39(5):2447-55. doi: 10.1118/1.3700400.
The use of laser accelerators in radiation therapy can perhaps increase the low number of proton and ion therapy facilities in some years due to the low investment costs and small size. The laser-based acceleration technology leads to a very high peak dose rate of about 10(11) Gy∕s. A first dosimetric task is the evaluation of dose rate dependence of clinical dosimeters and other detectors.
The measurements were done at ELBE, a superconductive linear electron accelerator which generates electron pulses with 5 ps length at 20 MeV. The different dose rates are reached by adjusting the number of electrons in one beam pulse. Three clinical dosimeters (TLD, OSL, and EBT radiochromic films) were irradiated with four different dose rates and nearly the same dose. A faraday cup, an integrating current transformer, and an ionization chamber were used to control the particle flux on the dosimeters. Furthermore two diamond detectors were tested.
The dosimeters are dose rate independent up to 4●10(9) Gy∕s within 2% (OSL and TLD) and up to 15●10(9) Gy∕s within 5% (EBT films). The diamond detectors show strong dose rate dependence.
TLD, OSL dosimeters, and EBT films are suitable for pulsed beams with a very high pulse dose rate like laser accelerated particle beams.
由于投资成本低和体积小,激光加速器在放射治疗中的应用可能会在未来几年增加质子和离子治疗设施的数量。基于激光的加速技术可实现约 10(11) Gy∕s 的非常高的峰值剂量率。第一个剂量学任务是评估临床剂量计和其他探测器的剂量率依赖性。
测量是在 ELBE 上进行的,ELBE 是一种超导线性电子加速器,可在 20 MeV 时产生 5 ps 长度的电子脉冲。通过调整一个束脉冲中的电子数量,可以达到不同的剂量率。三种临床剂量计(TLD、OSL 和 EBT 光致变色胶片)在四种不同的剂量率和几乎相同的剂量下进行了辐照。法拉第杯、积分电流互感器和电离室用于控制剂量计上的粒子通量。此外,还测试了两个金刚石探测器。
剂量计在 4●10(9) Gy∕s 内的剂量率依赖性小于 2%(OSL 和 TLD),在 15●10(9) Gy∕s 内的剂量率依赖性小于 5%(EBT 胶片)。金刚石探测器显示出强烈的剂量率依赖性。
TLD、OSL 剂量计和 EBT 胶片适用于具有非常高脉冲剂量率的脉冲束,如激光加速粒子束。