胸腺细胞前体细胞衰老的遗传调控。
Genetic regulation of thymocyte progenitor aging.
机构信息
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States.
出版信息
Semin Immunol. 2012 Oct;24(5):303-8. doi: 10.1016/j.smim.2012.04.006. Epub 2012 May 2.
Abstract
The number of T cell progenitors is significantly reduced in the involuted thymus, and the growth and developmental potential of the few cells that are present is severely attenuated. This review provides an overview of how aging affects T cell precursors before and following entry into the thymus and discusses the age-related genetic changes that may occur in them. Finally, interventions that rejuvenate thymopoiesis in the elderly by targeting T cell progenitors are discussed.
摘要
退化的胸腺中 T 细胞前体的数量显著减少，而存在的少数细胞的生长和发育潜能严重减弱。这篇综述概述了衰老如何影响进入胸腺前后的 T 细胞前体，并讨论了它们可能发生的与年龄相关的遗传变化。最后，讨论了通过针对 T 细胞前体来恢复老年人胸腺生成的干预措施。
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