Thorax. 1990 Nov;45(11):835-40. doi: 10.1136/thx.45.11.835.
The effects of various smoking cessation strategies were studied in two multicentre trials with new patients attending hospital or a chest clinic because of a smoking related disease. In the first trial (study A, 1462 patients) the effect of the physician's usual advice to stop smoking was compared with the effect of the same advice reinforced by a signed agreement to stop smoking by a target date within the next week, two visits by a health visitor in the first six weeks, and a series of letters of encouragement from the physician. The second trial (study B, 1392 patients) compared (1) advice only, (2) advice supplemented by a signed agreement, (3) advice supplemented by a series of letters of encouragement, and (4) advice supplemented by a signed agreement and a series of letters of encouragement. Patients were reviewed at six months and those claiming to have stopped smoking were seen again at 12 months. Claims of abstinence were checked by carboxyhaemoglobin measurement. In study A 9% of the intervention group had succeeded in stopping smoking at six months compared with 7% of the "advice only" patients (p = 0.17). In study B success rates were 5.2%, 4.9%, 8.5%, and 8.8% respectively. The signed agreement did not influence outcome, whereas postal encouragement increased the effect of the physician's advice. In both studies patients reviewed clinically between the initial and the six month visit were more likely to stop smoking than those not reviewed. Success rates increased with age and men tended to do better than women. The studies suggest that physician's advice alone will persuade 5% of outpatients with a smoking related disease to stop smoking. Subsequent postal encouragement will increase the cessation rate by more than half as much again. Such small improvements in success rates are worth while, especially if they can be achieved cheaply and on a wide scale.
在两项多中心试验中,对因吸烟相关疾病前往医院或胸部诊所就诊的新患者采用了各种戒烟策略并研究其效果。在第一项试验(研究A,1462名患者)中,将医生常规的戒烟建议效果与以下强化建议的效果进行了比较:签署一份在下周内的目标日期戒烟的协议、健康访视员在前六周进行两次家访以及医生发出一系列鼓励信。第二项试验(研究B,1392名患者)比较了:(1)仅提供建议;(2)提供建议并辅以签署协议;(3)提供建议并辅以一系列鼓励信;(4)提供建议并辅以签署协议和一系列鼓励信。在六个月时对患者进行复查,自称已戒烟的患者在12个月时再次接受检查。通过测量碳氧血红蛋白来核实戒烟声明。在研究A中,干预组9%的患者在六个月时成功戒烟,而“仅接受建议”的患者为7%(p = 0.17)。在研究B中,成功率分别为5.2%、4.9%、8.5%和8.8%。签署协议并未影响结果,而邮寄鼓励信增强了医生建议的效果。在两项研究中,在初次就诊和六个月就诊之间接受临床复查的患者比未接受复查的患者更有可能戒烟。成功率随年龄增长而提高,男性往往比女性做得更好。研究表明,仅医生的建议就能说服5%患有吸烟相关疾病的门诊患者戒烟。随后的邮寄鼓励将使戒烟率再提高一半以上。成功率如此小的提高是值得的,尤其是如果能以低成本广泛实现的话。