碳氧血红蛋白和血浆硫氰酸盐：吸烟行为的互补指标？
Carboxyhaemoglobin and plasma thiocyanate: complementary indicators of smoking behaviour?
作者信息
Saloojee Y, Vesey C J, Cole P V, Russell M A
出版信息
Thorax. 1982 Jul;37(7):521-5. doi: 10.1136/thx.37.7.521.
Carboxyhaemoglobin and plasma thiocyanate concentrations were measured in 79 non-smokers and 360 cigarette smokers. The mean levels were 0.73% and 7.09% carboxyhaemoglobin and 40 . 2 and 133 . 8 mumol thiocyanate/1 plasma respectively. With 1 . 6% carboxyhaemoglobin and 73 . 0 mumol thiocyanate/1 plasma as critical values the concentrations of carboxyhaemoglobin in 96.6% of subjects and of thiocyanate in 93.4% were compatible with reported smoking status. This difference between the two tests is significant (p less than 0 . 005). Statistical combination of the carboxyhaemoglobin and thiocyanate results, with the use of linear discrimination analysis, only marginally improved their diagnostic efficiency (96.8% of subjects were grouped correctly). This analysis did, however, successfully regroup 21 of 26 individuals with contradictory carboxyhaemoglobin and thiocyanate classifications. It is concluded that in this study determination of thiocyanate added little to the information obtained from carboxyhaemoglobin measurements alone.
对79名不吸烟者和360名吸烟者测量了碳氧血红蛋白和血浆硫氰酸盐浓度。平均水平分别为碳氧血红蛋白0.73%和7.09%，血浆硫氰酸盐分别为40.2和133.8μmol/1。以1.6%的碳氧血红蛋白和73.0μmol硫氰酸盐/1血浆作为临界值，96.6%的受试者碳氧血红蛋白浓度和93.4%的受试者硫氰酸盐浓度与报告的吸烟状况相符。这两项检测之间的差异具有显著性（p小于0.005）。使用线性判别分析对碳氧血红蛋白和硫氰酸盐结果进行统计合并，仅略微提高了它们的诊断效率（96.8%的受试者被正确分组）。然而，该分析确实成功地将26名碳氧血红蛋白和硫氰酸盐分类相互矛盾的个体中的21名重新分组。得出的结论是，在本研究中，硫氰酸盐的测定对仅从碳氧血红蛋白测量中获得的信息增加不多。
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