在小鼠急性脊髓损伤模型中评估切托菌素对组织病理学特征的影响。

Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model.

作者信息

Bravo-Reyna Carlos César, Miranda-Galván Vladimir, Reyes-Soto Gervith, Vicuña R, Alanis-Mendizabal Jorge, Escobar-Valderrama Manuel, Arango David, Bautista Claudia J, Ramírez Victoria, Torres-Villalobos Gonzalo

机构信息

Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico.

Oncologic Neurosurgery Unit, Instituto Nacional de Cancerología, Tlalpan, Zip code 14080, Mexico.

出版信息

World Neurosurg X. 2024 Sep 26;25:100414. doi: 10.1016/j.wnsx.2024.100414. eCollection 2025 Jan.

BACKGROUND

Several research studies have been focused on improving the treatment and prognosis of acute spinal cord injury, as part of this initiative we investigated the use of Chetomin to reduce the inflammatory response in this pathology.

METHODS

An experimental, prospective, cross-sectional study was performed using 42 Wistar rats where we analyzed the effect of Chetomin compared to methylprednisolone administered 1 and 8 h after the spinal cord injury in a murine model.

RESULTS

Chetomin administration 8h post-injury decreased IL-6 and VEGF expression; and, and its administration 1h post-injury decreased NF-kB expression.

CONCLUSIONS

Chetomin has anti-inflammatory effects in acute spinal cord injury, whether these effects are observable with other proinflammatory markers should be investigated.