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Doxorubicin and MBO-asGCS oligonucleotide loaded lipid nanoparticles overcome multidrug resistance in adriamycin resistant ovarian cancer cells (NCI/ADR-RES).阿霉素和 MBO-asGCS 寡核苷酸负载的脂质纳米粒克服了多柔比星耐药卵巢癌细胞（NCI/ADR-RES）的多药耐药性。
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本文引用的文献

1
Up-regulation of glucosylceramide synthase in urinary bladder neoplasms.尿路上皮肿瘤中葡萄糖神经酰胺合成酶的上调。
Urol Oncol. 2012 Jul-Aug;30(4):444-9. doi: 10.1016/j.urolonc.2010.04.012. Epub 2010 Sep 16.
2
Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: in vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells.混合骨架反义葡糖神经酰胺合酶寡核苷酸（MBO-asGCS）负载固体脂质纳米粒：体外特性分析及其对 NCI/ADR-RES 细胞多药耐药的逆转作用。
Int J Pharm. 2010 Nov 15;400(1-2):251-9. doi: 10.1016/j.ijpharm.2010.08.044. Epub 2010 Sep 15.
3
Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.葡萄糖神经酰胺合酶通过 cSrc 和β-连环蛋白信号上调 MDR1 表达调节肿瘤药物耐药性。
Mol Cancer. 2010 Jun 11;9:145. doi: 10.1186/1476-4598-9-145.
4
Multidrug resistance in oral squamous cell carcinoma: The role of vacuolar ATPases.口腔鳞状细胞癌中的多药耐药性：液泡型 ATP 酶的作用。
Cancer Lett. 2010 Sep 28;295(2):135-43. doi: 10.1016/j.canlet.2010.03.019. Epub 2010 Apr 24.
5
Targeting nanoparticles to cancer.靶向纳米颗粒治疗癌症。
Pharmacol Res. 2010 Aug;62(2):90-9. doi: 10.1016/j.phrs.2010.03.005. Epub 2010 Apr 7.
6
Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia.研制伊达比星和多柔比星固体脂质纳米粒以克服白血病中的 Pgp 介导的多药耐药性。
J Biomed Nanotechnol. 2009 Apr;5(2):151-61. doi: 10.1166/jbn.2009.1021.
7
A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis.一种新型混合骨干寡核苷酸针对葡萄糖神经酰胺合酶使多药耐药肿瘤对细胞凋亡敏感。
PLoS One. 2009 Sep 9;4(9):e6938. doi: 10.1371/journal.pone.0006938.
8
Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP.载有多柔比星和紫杉醇的脂质纳米粒通过抑制P-糖蛋白和消耗三磷酸腺苷来克服多药耐药性。
Cancer Res. 2009 May 1;69(9):3918-26. doi: 10.1158/0008-5472.CAN-08-2747. Epub 2009 Apr 21.
9
Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif.阿霉素的化学毒性和P-糖蛋白（多药耐药蛋白1，MDR1）的表面表达受铜绿假单胞菌毒素Cif调控。
Am J Physiol Cell Physiol. 2008 Sep;295(3):C807-18. doi: 10.1152/ajpcell.00234.2008. Epub 2008 Jul 23.
10
A role for ceramide in driving cancer cell resistance to doxorubicin.神经酰胺在驱动癌细胞对多柔比星耐药中的作用。
FASEB J. 2008 Jul;22(7):2541-51. doi: 10.1096/fj.07-092981. Epub 2008 Feb 1.

阿霉素和 MBO-asGCS 寡核苷酸负载的脂质纳米粒克服了多柔比星耐药卵巢癌细胞（NCI/ADR-RES）的多药耐药性。

Doxorubicin and MBO-asGCS oligonucleotide loaded lipid nanoparticles overcome multidrug resistance in adriamycin resistant ovarian cancer cells (NCI/ADR-RES).

机构信息

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209-0497, USA.

出版信息

Int J Pharm. 2012 Jul 15;431(1-2):222-9. doi: 10.1016/j.ijpharm.2012.04.050. Epub 2012 Apr 25.

DOI:10.1016/j.ijpharm.2012.04.050
PMID:22562053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3358787/
Abstract

The objective of this study was to increase the potency of doxorubicin against adriamycin-resistant NCI/ADR-RES cells by concurrent treatment with doxorubicin and MBO-asGCS loaded solid-lipid nanoparticles (SLN). Loading doxorubicin as ion-pair complex with deoxytaurocholate into cationic and neutral SLN was investigated. Fast release and poor entrapment were observed in cationic nanoparticles, which were corrected by entrapping the complex in neutral polyoxyethylene (20) stearyl ether (Brij(®) 78)/VitE-TPGS nanoparticles. Slow doxorubicin release confirmed the influence of charge and electrolytes on the dissociation of ion-pair complexes. To evaluate antitumor activity, NCI/ADR-RES cells were treated with separate SLN: one loaded with doxorubicin and another carrying MBO-asGCS oligonucleotide. The viability of cells treated with 5 μM doxorubicin was reduced to 17.2% whereas viability was reduced to 2.5% for cells treated with both 5 μM doxorubicin SLN and 100 nM MBO-asGCS SLN. This suggested enhanced apoptosis due to sensitization and effective intracellular delivery of MBO-asGCS and doxorubicin by SLN.

摘要

本研究的目的是通过同时给予阿霉素和载 MBO-asGCS 的固体脂质纳米粒（SLN）来提高多柔比星对阿霉素耐药的 NCI/ADR-RES 细胞的效力。考察了将阿霉素与脱氧牛磺胆酸钠形成离子对复合物载入阳离子和中性 SLN 中。阳离子纳米粒中观察到快速释放和较差的包封，通过将复合物包封在中性聚氧乙烯（20）硬脂醚（Brij®78）/VitE-TPGS 纳米粒中得到了纠正。缓慢的阿霉素释放证实了电荷和电解质对离子对复合物解离的影响。为了评估抗肿瘤活性，用单独的 SLN 处理 NCI/ADR-RES 细胞：一种负载阿霉素，另一种携带 MBO-asGCS 寡核苷酸。用 5 μM 阿霉素处理的细胞活力降低至 17.2%，而用 5 μM 阿霉素 SLN 和 100 nM MBO-asGCS SLN 处理的细胞活力降低至 2.5%。这表明由于 SLN 对 MBO-asGCS 和阿霉素的增敏作用以及有效的细胞内递送，导致细胞凋亡增加。