University of Pennsylvania, USA.
Neuroimage. 2012 Aug 15;62(2):1279-85. doi: 10.1016/j.neuroimage.2012.04.039. Epub 2012 Apr 26.
Arterial spin labeled (ASL), perfusion fMRI was developed nearly simultaneously with BOLD fMRI. The application of this technique in studies of human brain activity has grown slowly over the last twenty years, primarily because of the need to meet technical challenges in data acquisition and analysis. Even within these constraints, perfusion fMRI has been identified as a tool that is well suited to measure slow changes in neural activity and to examine individual differences in brain-behavior relationships. Major advances have been made in acquisition and analysis techniques during this time. With further, anticipated technical improvements, perfusion fMRI studies in humans are poised to gain the improved cortical spatial resolution that has been observed in animal studies. If achieved, these advances portend surprising future applications of perfusion fMRI, including multi-voxel pattern analysis.
动脉自旋标记（ASL）灌注 fMRI 与 BOLD fMRI 几乎同时发展起来。这项技术在人类大脑活动研究中的应用在过去二十年中发展缓慢，主要是因为需要满足数据采集和分析方面的技术挑战。即使在这些限制下，灌注 fMRI 也被认为是一种非常适合测量神经活动缓慢变化和研究大脑-行为关系个体差异的工具。在此期间，在采集和分析技术方面取得了重大进展。随着进一步的预期技术改进，预计人类的灌注 fMRI 研究将获得在动物研究中观察到的改进的皮质空间分辨率。如果实现，这些进展预示着灌注 fMRI 的未来应用将有惊人的发展，包括多体素模式分析。
