Opatrný K, Pittrová H, Opatrný K, Kováríková P, Cerhová M, Rusnáková H
Interní oddĕlení Strahov, fakultní nemocnice 2 s fakultní polikinikou, Praha.
Vnitr Lek. 1990 Oct;36(10):978-84.
The authors compared 10 pairs of membrane plasmaphereses on an apparatus A 2008 PF and filter Plasmaflux P 2 with 10 centrifugation plasmaphereses on an apparatus Fenwal CS 3000. They evaluated the effectiveness by changes of plasma concentrations of total protein, albumin, beta 2 microglobulin, IgG, IgA, C3 complement, IgM, circulating immune complexes, urea, creatinine, uric acid, cholesterol, triacylglycerols and the clearance of these substances. Changes of plasma concentrations caused by plasmapheresis with the methods used did not differ in any of the investigated substances. The clearance of membrane plasmapheresis was for all substances higher than when the centrifugation method was used. Among values from which the clearance is determined no difference was proved between the two methods in the volume of exchanged plasma, the concentration of the substance in the removed plasma and its mid plasma concentration during the operation. The higher clearance of membrane plasmapheresis was due to the more rapid plasma exchange.
作者将在A 2008 PF设备上进行的10对膜式血浆置换与使用Plasmaflux P 2过滤器的情况，与在Fenwal CS 3000设备上进行的10次离心式血浆置换进行了比较。他们通过总蛋白、白蛋白、β2微球蛋白、IgG、IgA、C3补体、IgM、循环免疫复合物、尿素、肌酐、尿酸、胆固醇、三酰甘油的血浆浓度变化以及这些物质的清除率来评估有效性。使用所采用的方法进行血浆置换所引起的血浆浓度变化，在任何被研究物质中均无差异。膜式血浆置换对所有物质的清除率均高于使用离心法时的清除率。在确定清除率的各项数值中，两种方法在置换血浆量、去除血浆中物质的浓度及其术中血浆中间浓度方面均未证明存在差异。膜式血浆置换较高的清除率归因于更快的血浆置换速度。
