非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂IEM-1957和美金刚在实验性局灶性脑缺血中的神经保护作用 - Suppr

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超能文献

Neuroprotective effect of noncompetitive NMDA receptor antagonists IEM-1957 and memantine in experimental focal cerebral ischemia.

作者信息

Kalemenev S V, Zubareva O E, Lukomskaya N Ya, Magazanik L G

机构信息

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.

出版信息

Dokl Biol Sci. 2012 Mar-Apr;443:78-80. doi: 10.1134/S0012496612020184. Epub 2012 May 5.

DOI:10.1134/S0012496612020184

PMID:22562673

Abstract

摘要

相似文献

Neuroprotective effect of noncompetitive NMDA receptor antagonists IEM-1957 and memantine in experimental focal cerebral ischemia.非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂IEM-1957和美金刚在实验性局灶性脑缺血中的神经保护作用

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Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation.N-甲基-D-天冬氨酸开放通道阻滞剂美金刚的神经保护浓度在缺血后给药时有效且不会导致细胞质空泡化，并且不会阻断迷宫学习或长时程增强。

Neuroscience. 1998 Oct;86(4):1121-32. doi: 10.1016/s0306-4522(98)00163-8.

Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro.还原条件会显著减弱竞争性NMDA受体拮抗剂（而非其他NMDA受体拮抗剂）在体外的神经保护功效。

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Reduction of edema and infarction by Memantine and MK-801 after focal cerebral ischaemia and reperfusion in rat.美金刚和MK-801对大鼠局灶性脑缺血再灌注后水肿和梗死的减轻作用

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Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol.缺血性卒中的联合治疗：美金刚与克伦特罗的协同神经保护作用

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Therapeutically relevant plasma concentrations of memantine produce significant L-N-methyl-D-aspartate receptor occupation and do not impair learning in rats.美金刚具有治疗相关性的血浆浓度可产生显著的 N-甲基-D-天冬氨酸受体占有率，且不会损害大鼠的学习能力。

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Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats.美金刚（一种非竞争性N-甲基-D-天冬氨酸受体拮抗剂）对大鼠创伤性脑损伤后的神经保护作用。

Brain Res. 2001 Aug 17;911(1):96-100. doi: 10.1016/s0006-8993(01)02617-8.

Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.金刚烷胺和美金刚是具有神经保护特性的N-甲基-D-天冬氨酸受体拮抗剂。

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The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice.新型多胺拮抗剂N1-丹磺酰精胺在小鼠永久性局灶性脑缺血模型中的缺血前神经保护作用。

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N-methyl-D-aspartate receptor channel blockers prevent pentylenetetrazole-induced convulsions and morphological changes in rat brain neurons.N-甲基-D-天冬氨酸受体通道阻滞剂可预防戊四氮诱导的大鼠脑神经元惊厥和形态学变化。

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Memantine as a neuroprotective agent in ischemic stroke: Preclinical and clinical analysis.美金刚作为缺血性脑卒中的神经保护剂：临床前与临床分析

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本文引用的文献

Pre-ischemic treatment with memantine reversed the neurochemical and behavioural parameters but not energy metabolites in middle cerebral artery occluded rats.在大脑中动脉闭塞大鼠中，美金刚的缺血预处理逆转了神经化学和行为参数，但未逆转能量代谢物。

Pharmacol Biochem Behav. 2009 May;92(3):424-32. doi: 10.1016/j.pbb.2009.01.010. Epub 2009 Jan 23.

Influence of memantine on brain monoaminergic neurotransmission parameters in mice: neurochemical and behavioral study.美金刚对小鼠脑单胺能神经传递参数的影响：神经化学与行为学研究。

Biol Pharm Bull. 2009 May;32(5):850-5. doi: 10.1248/bpb.32.850.

Anti-dementia drugs and hippocampal-dependent memory in rodents.抗痴呆药物与啮齿动物海马依赖性记忆

Behav Pharmacol. 2007 Sep;18(5-6):347-63. doi: 10.1097/FBP.0b013e3282da278d.

[Involvement of ionotropic glutamate receptors in the genesis of arecoline-induced tremor].

Ross Fiziol Zh Im I M Sechenova. 2007 Mar;93(3):275-82.

Low doses of memantine disrupt memory in adult rats.低剂量美金刚会干扰成年大鼠的记忆。

J Neurosci. 2006 Apr 12;26(15):3923-32. doi: 10.1523/JNEUROSCI.4883-05.2006.

Design of antagonists for NMDA and AMPA receptors.N-甲基-D-天冬氨酸（NMDA）受体和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体拮抗剂的设计

Neuropharmacology. 2005 Aug;49(2):144-55. doi: 10.1016/j.neuropharm.2005.02.007.

Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults.N-甲基-D-天冬氨酸受体拮抗剂的失败与成功：使用美金刚等开放通道阻滞剂治疗急慢性神经损伤的分子基础。

NeuroRx. 2004 Jan;1(1):101-10. doi: 10.1602/neurorx.1.1.101.

[Role of NMDA and AMPA glutamate receptors in the mechanism of korazol-induced convulsions in mice].

Ross Fiziol Zh Im I M Sechenova. 2003 Mar;89(3):292-301.

External carotid artery territory ischemia impairs outcome in the endovascular filament model of middle cerebral artery occlusion in rats.大鼠大脑中动脉闭塞血管内丝线模型中，颈外动脉供血区缺血会损害预后。

Stroke. 2003 Sep;34(9):2252-7. doi: 10.1161/01.STR.0000083625.54851.9A. Epub 2003 Jul 31.

Filament size influences temperature changes and brain damage following middle cerebral artery occlusion in rats.细丝大小影响大鼠大脑中动脉闭塞后的温度变化和脑损伤。

Exp Brain Res. 2002 Jan;142(1):131-8. doi: 10.1007/s00221-001-0909-4. Epub 2001 Oct 31.

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