Nekrasova A A, Kiseleva Z M, Ustinova S E, Uchitel' I A, Zharova E A
Kardiologiia. 1977 Oct;17(10):19-27.
Study of the hormone content and enzyme activity in patients with hypertensive disease at rest and in various types of stimulation revealed predominance of pressor humoral systems over depressor ones. With the development of the disease, the reaction of these humoral systems to stimulation diminishes. Decrease of the renin-angiotensin-aldosterone system compensatory reaction and the prostaglandin F level in patients with stable, high arterial pressur in response to furosemide administration may be among the causes of the hypotensive and natriuretic effect of this preparation. Activization of the humoral depressor systems in the initial stage of the disease is conducive to the preservation of the water-electrolyte hemostasis in the organism and maintains the labile level of arterial pressure despite the increased activity of the natrium-retaining hormones. Exhaustion of the humoral depressor systems may be one of the causes of arterial pressure stabilization.
对高血压病患者静息及各种类型刺激下的激素含量和酶活性进行研究发现，升压体液系统占优势，降压体液系统处于劣势。随着疾病的发展，这些体液系统对刺激的反应减弱。在动脉血压稳定且较高的患者中，给予速尿后肾素 - 血管紧张素 - 醛固酮系统代偿反应及前列腺素F水平降低，可能是该制剂产生降压和利钠作用的原因之一。疾病初期体液降压系统的激活有助于维持机体水电解质平衡，尽管保钠激素活性增加，但仍能维持动脉血压的不稳定水平。体液降压系统的耗竭可能是动脉血压稳定的原因之一。
