铜绿假单胞菌中初级代谢与次级代谢交汇点处的分解代谢物阻遏控制对绿脓菌素生物合成的影响。
Catabolite repression control of pyocyanin biosynthesis at an intersection of primary and secondary metabolism in Pseudomonas aeruginosa.
机构信息
School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, People’s Republic of China.
出版信息
Appl Environ Microbiol. 2012 Jul;78(14):5016-20. doi: 10.1128/AEM.00026-12. Epub 2012 May 4.
Abstract
In Pseudomonas aeruginosa, the catabolite repression control (Crc) protein repressed the formation of the blue pigment pyocyanin in response to a preferred carbon source (succinate) by interacting with phzM mRNA, which encodes a key enzyme in pyocyanin biosynthesis. Crc bound to an extended imperfect recognition sequence that was interrupted by the AUG translation initiation codon.
摘要
在铜绿假单胞菌中，分解代谢物阻遏控制（Crc）蛋白通过与编码蓝脓菌素生物合成关键酶的 phzM mRNA 相互作用，响应首选碳源（琥珀酸盐）来抑制蓝脓菌素的形成。Crc 结合到一个延伸的不完美识别序列上，该序列被 AUG 翻译起始密码子中断。
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