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本文引用的文献

1
Honey's Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition.蜂蜜对抗细菌感染的能力源于杀菌化合物和群体感应抑制。
Front Microbiol. 2012 Apr 11;3:144. doi: 10.3389/fmicb.2012.00144. eCollection 2012.
2
Two small RNAs, CrcY and CrcZ, act in concert to sequester the Crc global regulator in Pseudomonas putida, modulating catabolite repression.两个小 RNA，CrcY 和 CrcZ，协同作用将 Pseudomonas putida 中的 Crc 全局调节物隔离，调节分解代谢物阻遏。
Mol Microbiol. 2012 Jan;83(1):24-40. doi: 10.1111/j.1365-2958.2011.07912.x. Epub 2011 Nov 20.
3
Small RNAs as regulators of primary and secondary metabolism in Pseudomonas species.小 RNA 作为假单胞菌中初级和次级代谢的调节剂。
Appl Microbiol Biotechnol. 2011 Jul;91(1):63-79. doi: 10.1007/s00253-011-3332-1. Epub 2011 May 24.
4
Phenazine-1-carboxylic acid promotes bacterial biofilm development via ferrous iron acquisition.吩嗪-1-羧酸通过获取二价铁促进细菌生物膜的形成。
J Bacteriol. 2011 Jul;193(14):3606-17. doi: 10.1128/JB.00396-11. Epub 2011 May 20.
5
Promoter recognition and activation by the global response regulator CbrB in Pseudomonas aeruginosa.铜绿假单胞菌中全局性调控因子 CbrB 对启动子的识别与激活
J Bacteriol. 2011 Jun;193(11):2784-92. doi: 10.1128/JB.00164-11. Epub 2011 Apr 8.
6
The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa.全局调控因子 Crc 调节铜绿假单胞菌的代谢、抗生素易感性和毒力。
Environ Microbiol. 2010 Dec;12(12):3196-212. doi: 10.1111/j.1462-2920.2010.02292.x.
7
The Crc global regulator inhibits the Pseudomonas putida pWW0 toluene/xylene assimilation pathway by repressing the translation of regulatory and structural genes.Crc 全局调节因子通过抑制调节基因和结构基因的翻译来抑制恶臭假单胞菌 pWW0 甲苯/二甲苯同化途径。
J Biol Chem. 2010 Aug 6;285(32):24412-9. doi: 10.1074/jbc.M110.126615. Epub 2010 Jun 7.
8
Carbon catabolite repression in Pseudomonas : optimizing metabolic versatility and interactions with the environment.假单胞菌中的碳分解代谢物阻遏：优化代谢多样性和与环境的相互作用。
FEMS Microbiol Rev. 2010 Sep;34(5):658-84. doi: 10.1111/j.1574-6976.2010.00218.x. Epub 2010 Mar 10.
9
Small RNA as global regulator of carbon catabolite repression in Pseudomonas aeruginosa.小 RNA 作为铜绿假单胞菌碳分解代谢物阻遏作用的全局调控因子。
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21866-71. doi: 10.1073/pnas.0910308106.
10
The Crc global regulator binds to an unpaired A-rich motif at the Pseudomonas putida alkS mRNA coding sequence and inhibits translation initiation.Crc 全局调节因子结合到 Pseudomonas putida alkS mRNA 编码序列中的未配对的富含 A 的基序上，并抑制翻译起始。
Nucleic Acids Res. 2009 Dec;37(22):7678-90. doi: 10.1093/nar/gkp825.

铜绿假单胞菌中初级代谢与次级代谢交汇点处的分解代谢物阻遏控制对绿脓菌素生物合成的影响。

Catabolite repression control of pyocyanin biosynthesis at an intersection of primary and secondary metabolism in Pseudomonas aeruginosa.

机构信息

School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, People’s Republic of China.

出版信息

Appl Environ Microbiol. 2012 Jul;78(14):5016-20. doi: 10.1128/AEM.00026-12. Epub 2012 May 4.

DOI:10.1128/AEM.00026-12
PMID:22562990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3416368/
Abstract

In Pseudomonas aeruginosa, the catabolite repression control (Crc) protein repressed the formation of the blue pigment pyocyanin in response to a preferred carbon source (succinate) by interacting with phzM mRNA, which encodes a key enzyme in pyocyanin biosynthesis. Crc bound to an extended imperfect recognition sequence that was interrupted by the AUG translation initiation codon.

摘要

在铜绿假单胞菌中，分解代谢物阻遏控制（Crc）蛋白通过与编码蓝脓菌素生物合成关键酶的 phzM mRNA 相互作用，响应首选碳源（琥珀酸盐）来抑制蓝脓菌素的形成。Crc 结合到一个延伸的不完美识别序列上，该序列被 AUG 翻译起始密码子中断。