Respiratory Medicine and Pulmonary Rehabilitation, Clinic Center Private Hospital, Naples, Italy, Viale Maria Bakunin n. 171 CAP 80126 Napoli.
Ther Adv Respir Dis. 2012 Aug;6(4):221-37. doi: 10.1177/1753465812444712. Epub 2012 May 4.
Chronic obstructive pulmonary disease (COPD) is a chronic condition that negatively affects several patient-centered outcomes. Among these, exercise capacity, dyspnea, and quality of life are the most relevant. In this article, factors contributing to exercise limitation, increase in exercise-induced dyspnea, quality of life deterioration, and other pathophysiological aspects in patients with COPD are analyzed in detail. Pulmonary rehabilitation (PR) is an evidence-based, multidisciplinary, and comprehensive intervention for patients with chronic respiratory diseases who are symptomatic and often have decreased daily life activities. PR has been clearly shown to induce favorable and long-lasting effects on all patient-centered outcomes. In addition, PR appears to have positive (even if not conclusively demonstrated) effects on other important outcomes in patients with COPD: number and severity of exacerbations, healthcare resource utilization, and survival. The organization of PR treatment, its components, outcome assessment, and future directions are discussed in light of the most robust scientific evidence.
慢性阻塞性肺疾病（COPD）是一种慢性病，会对多项以患者为中心的结局产生负面影响。在这些结局中，运动能力、呼吸困难和生活质量是最相关的。本文详细分析了导致 COPD 患者运动受限、运动诱导性呼吸困难增加、生活质量恶化和其他病理生理方面的因素。肺康复（PR）是一种基于证据的、多学科的、综合性的干预措施，适用于有症状且日常生活活动经常减少的慢性呼吸系统疾病患者。PR 已被明确证明对所有以患者为中心的结局产生有利且持久的影响。此外，PR 似乎对 COPD 患者的其他重要结局（如加重的次数和严重程度、医疗资源利用和生存）有积极影响（即使尚未得到明确证实）。本文根据最有力的科学证据，讨论了 PR 治疗的组织、组成部分、结局评估和未来方向。
