Soriano M L, Martínez N, Grilli R, Fariña M C, Martín L, Requena L
Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Mar;87(3):322-6. doi: 10.1016/s1079-2104(99)70216-7.
Pyodermatitis-pyostomatitis vegetans is a benign, rare disorder characterized by a pustular eruption in the oral mucosa and vegetating plaques involving the groin and axillary folds. Its association with inflammatory bowel disease is well established. We report the case of a 49-year-old-white man with ulcerative colitis who manifested a vegetating, annular plaque in the left inguinal region of 2 months' duration. Oral examination disclosed an erythematous mucosa with multiple painful pustules involving the labial and gingival mucosa. Histopathologic study demonstrated epidermal hyperplasia and an inflammatory infiltrate composed mostly of neutrophils and eosinophils, grouped into microabscesses within the epidermis and with a bandlike configuration in the upper dermis. Results of direct and indirect immunofluorescence studies were negative. We discuss the differential diagnosis between pyodermatitis-pyostomatitis vegetans and pemphigus vegetans.
增殖性皮炎-增殖性口炎是一种罕见的良性疾病，其特征为口腔黏膜出现脓疱疹以及腹股沟和腋窝褶皱处出现增殖性斑块。它与炎症性肠病的关联已得到充分证实。我们报告一例49岁白人男性溃疡性结肠炎患者，其左侧腹股沟区出现一个持续2个月的增殖性环状斑块。口腔检查发现黏膜红斑，唇黏膜和牙龈黏膜有多个疼痛性脓疱。组织病理学研究显示表皮增生，炎症浸润主要由中性粒细胞和嗜酸性粒细胞组成，在表皮内形成微脓肿，在真皮上层呈带状分布。直接和间接免疫荧光研究结果均为阴性。我们讨论了增殖性皮炎-增殖性口炎与增殖性天疱疮的鉴别诊断。
