Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
Br J Dermatol. 2012 Oct;167(4):762-7. doi: 10.1111/j.1365-2133.2012.11038.x. Epub 2012 Aug 20.
Plaque-type psoriasis manifests with various morphological phenotypes and different clinical activity over time in the same individual or from one patient to another. Circulating cytokines, especially T-helper (Th) 1- and Th17-related, have been suggested to reflect the inflammatory nature of psoriasis. However, studies regarding cytokine profile according to morphological phenotypes are quite scarce.
We sought to analyse the circulating Th1 and Th17 cytokines according to clinical phenotype and investigated the correlation between disease severity [Psoriasis Area and Severity Index (PASI)] and the serum level of inflammatory cytokines.
Seventy-one patients with psoriasis were divided into two groups according to clinical phenotype: chronic stable (CS) and eruptive inflammatory (EI). Th1- and Th17-derived cytokines were measured using multiplex cytokine assay.
It was noted that interleukin (IL)-1 receptor antagonist and IL-17A were elevated in the EI group compared with the CS group. We also noticed that the PASI is relatively well correlated with serum cytokine level in the CS state but not as well in the EI counterpart.
The level of serum inflammatory cytokines differs according to morphological phenotype. Also, the PASI does not seem to be a suitable tool to assess disease severity in patients with psoriasis with EI characteristics.
斑块型银屑病在同一患者或不同患者中随时间表现出不同的形态表型和不同的临床活动。循环细胞因子，尤其是辅助性 T 细胞（Th）1 和 Th17 相关细胞因子，被认为反映了银屑病的炎症性质。然而，关于根据形态表型的细胞因子谱的研究相当稀少。
我们旨在根据临床表型分析循环 Th1 和 Th17 细胞因子，并研究疾病严重程度[银屑病面积和严重程度指数（PASI）]与炎症细胞因子血清水平之间的相关性。
71 例银屑病患者根据临床表型分为两组：慢性稳定（CS）和爆发性炎症（EI）。使用多重细胞因子检测法测量 Th1 和 Th17 衍生细胞因子。
我们注意到，白细胞介素（IL）-1 受体拮抗剂和 IL-17A 在 EI 组中高于 CS 组。我们还注意到，在 CS 状态下，PASI 与血清细胞因子水平具有相对较好的相关性，但在 EI 对应组中则不然。
血清炎症细胞因子的水平根据形态表型而有所不同。此外，PASI 似乎不是评估具有 EI 特征的银屑病患者疾病严重程度的合适工具。
