水疱性口炎病毒核衣壳。
The nucleocapsid of vesicular stomatitis virus.
机构信息
Department of Microbiology, the University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
Sci China Life Sci. 2012 Apr;55(4):291-300. doi: 10.1007/s11427-012-4307-x. Epub 2012 May 9.
The nucleocapsid of vesicular stomatitis virus serves as the genomic template for transcription and replication. The viral genomic RNA is sequestered in the nucleocapsid in every step of the virus replication cycle. The structure of the nucleocapsid and the entire virion revealed how the viral genomic RNA is encapsidated and packaged in the virus. A unique mechanism for viral RNA synthesis is derived from the structure of the nuleocapsid and its interactions with the viral RNA-dependent RNA polymerase.
水疱性口炎病毒的核衣壳可作为转录和复制的基因组模板。病毒基因组 RNA 在病毒复制周期的每一步都被隔离在核衣壳中。核衣壳和整个病毒粒子的结构揭示了病毒基因组 RNA 是如何被包被和包装在病毒中的。病毒 RNA 合成的独特机制源自核衣壳的结构及其与病毒 RNA 依赖性 RNA 聚合酶的相互作用。
Zotero 插件