Department of Metallurgical Engineering and Materials, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
J Biomed Mater Res B Appl Biomater. 2012 Jul;100(5):1387-96. doi: 10.1002/jbm.b.32710. Epub 2012 May 7.
The development of polymer/bioactive glass has been recognized as a strategy to improve the mechanical behavior of bioactive glass-based materials. Several studies have reported systems based on bioactive glass/biopolymer composites. In this study, we developed a composite system based on bioactive glass nanoparticles (BGNP), obtained by a modified Stöber method. We also developed a new chemical route to obtain aqueous dispersive biodegradable polyurethane. The production of polyurethane/BGNP scaffolds intending to combine biocompatibility, mechanical, and physical properties in a material designed for tissue engineering applications. The composites obtained were characterized by structural, biological, and mechanical tests. The films presented 350% of deformation and the foams presented pore structure and mechanical properties adequate to support cell growth and proliferation. The materials presented good cell viability and hydroxyapatite layer formation upon immersion in simulated body fluid.
聚合物/生物活性玻璃的发展已被认为是改善基于生物活性玻璃材料的机械性能的一种策略。有几项研究报道了基于生物活性玻璃/生物聚合物复合材料的系统。在这项研究中，我们开发了一种基于生物活性玻璃纳米粒子（BGNP）的复合材料系统，该系统是通过改良的 Stöber 法获得的。我们还开发了一种新的化学途径来获得可生物降解的水性分散型聚氨酯。生产聚氨酯/BGNP 支架旨在将生物相容性、机械性能和物理性能结合在一种用于组织工程应用的材料中。通过结构、生物学和机械测试对获得的复合材料进行了表征。薄膜的变形达到了 350%，而泡沫则具有适当的孔结构和机械性能，足以支持细胞生长和增殖。这些材料在模拟体液中浸泡时表现出良好的细胞活力和羟基磷灰石层形成。
