Materials Science and Chemical Engineering Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
J Mater Sci Mater Med. 2009 Nov;20(11):2189-95. doi: 10.1007/s10856-009-3787-0. Epub 2009 Jun 2.
This research work aims to propose highly porous polymer/bioactive glass composites as potential scaffolds for hard-tissue and soft-tissue engineering. The scaffolds were prepared by impregnating an open-cells polyurethane sponge with melt-derived particles of a bioactive glass belonging to the SiO(2)-P(2)O(5)-CaO-MgO-Na(2)O-K(2)O system (CEL2). Both the starting materials and the composite scaffolds were investigated from a morphological and structural viewpoint by X-ray diffraction analysis and scanning electron microscopy. Tensile mechanical tests, carried out according to international ISO and ASTM standards, were performed by using properly tailored specimens. In vitro tests by soaking the scaffolds in simulated body fluid (SBF) were also carried out to assess the bioactivity of the porous composites. It was found that the composite scaffolds were highly bioactive as after 7 days of soaking in SBF a HA layer grew on their surface. The obtained polyurethane/CEL2 composite scaffolds are promising candidates for tissue engineering applications.
本研究旨在提出高多孔聚合物/生物活性玻璃复合材料作为硬组织和软组织工程的潜在支架。支架是通过将熔融衍生的 SiO(2)-P(2)O(5)-CaO-MgO-Na(2)O-K(2)O 系统（CEL2）生物活性玻璃的颗粒浸渍到开孔聚氨酯海绵中来制备的。从形态和结构的角度出发，通过 X 射线衍射分析和扫描电子显微镜对起始材料和复合支架进行了研究。根据国际 ISO 和 ASTM 标准进行了适当定制的试样的拉伸力学试验。还通过将支架浸泡在模拟体液（SBF）中进行了体外试验，以评估多孔复合材料的生物活性。结果发现，复合支架具有很高的生物活性，因为在 SBF 中浸泡 7 天后，HA 层在其表面生长。所得的聚氨酯/CEL2 复合支架是组织工程应用的有前途的候选物。
