Division of Reproductive Endocrinology and IVF Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Baskent University, Sumer mah. 69168 sok. Grand Park Plaza C Blok kat:12 No:24 Seyhan, Adana, Turkey.
Arch Gynecol Obstet. 2012 Sep;286(3):763-9. doi: 10.1007/s00404-012-2348-9. Epub 2012 May 9.
To compare the IVF/ICSI outcomes of the long GnRH agonist and the fixed GnRH antagonist protocol in women with PCOS.
Randomized controlled trial.
Baskent University Department of Obstetrics and Gynecology.
Three hundred women with PCOS.
IVF/ICSI following the long GnRH agonist down-regulation or the fixed GnRH antagonist protocols.
Ongoing pregnancy rates.
Ongoing pregnancy rates were 36.4 % in the OCP + GnRH agonist group and 35.9 % in the OCP + GnRH antagonist group (p > 0.05). Progesterone levels on the day of hCG (0.76 ± 0.71 vs. 0.58 ± 0.50), endometrial thickness on the day of hCG (11.57 ± 2.50 vs. 10.50 ± 2.01), total gonadotropin used (1388.71 ± 482.39 vs. 1253.25 ± 415.81), and duration of COH (9.07 ± 1.96 vs. 8.39 ± 1.75) were significantly lower in the OCP + GnRH antagonist group.
The OCP + long GnRH agonist and the OCP + fixed GnRH antagonist protocols yield similar ongoing pregnancy rates in women with PCOS. Although this study consisting three hundred patients, seems to be large enough in a single center, we were not able to reach to the actual size of power analysis which was approximately 3,000.
比较长 GnRH 激动剂和固定 GnRH 拮抗剂方案在多囊卵巢综合征（PCOS）患者中的 IVF/ICSI 结局。
随机对照试验。
Baskent 大学妇产科。
300 例 PCOS 患者。
长 GnRH 激动剂下调或固定 GnRH 拮抗剂方案后的 IVF/ICSI。
持续妊娠率。
OCP+GnRH 激动剂组的持续妊娠率为 36.4%，OCP+GnRH 拮抗剂组为 35.9%（p>0.05）。HCG 日孕酮水平（0.76±0.71 比 0.58±0.50）、HCG 日子宫内膜厚度（11.57±2.50 比 10.50±2.01）、总促性腺激素用量（1388.71±482.39 比 1253.25±415.81）和 COH 持续时间（9.07±1.96 比 8.39±1.75）在 OCP+GnRH 拮抗剂组显著降低。
OCP+长 GnRH 激动剂和 OCP+固定 GnRH 拮抗剂方案在 PCOS 患者中产生相似的持续妊娠率。尽管这项由 300 例患者组成的研究在单中心似乎足够大，但我们无法达到实际的功效分析规模，大约为 3000。
