N'-甲基尼菲霉素，一种来自链霉菌属57-13的新型尼菲霉素次要同系物。
N'-methylniphimycin, a novel minor congener of niphimycin from Streptomyces spec. 57-13.
作者信息
Ivanova V, Schlegel R, Dornberger K
机构信息
Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev, Sofia, Bulgaria.
出版信息
J Basic Microbiol. 1998;38(5-6):415-9. doi: 10.1002/(sici)1521-4028(199811)38:5/6<415::aid-jobm415>3.0.co;2-z.
A novel natural niphimycin analog, N'-methylniphimycin was isolated from the culture broth of the Streptomyces spec. 57-13. The chemical constitution was elucidated from the physico-chemical properties, NMR techniques and mass spectrometry to be a 36-membered macrolide related to azalomycin F5a, shurimycin B and RS-22C. N'-methylniphimycin displayed moderate activity against some yeasts and filamentous fungi.
一种新型的天然尼菲霉素类似物N'-甲基尼菲霉素是从链霉菌属57-13的培养液中分离出来的。通过物理化学性质、核磁共振技术和质谱分析确定其化学结构为一种与氮杂霉素F5a、舒里霉素B和RS-22C相关的36元大环内酯类化合物。N'-甲基尼菲霉素对一些酵母和丝状真菌表现出中等活性。
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