Goldman H, Murphy S, Schneider D R, Felt B T
Pharmacol Biochem Behav. 1979 Jun;10(6):883-7. doi: 10.1016/0091-3057(79)90062-5.
Regional cerebral blood flows (rCBF) were measured in conscious, male rats at 10, 30, 60 min and 24 hr after intravenous administration of a potent, behaviorally active analog of ACTH/MSH 4--9 (ORG-2766). Flows in the basal ganglia, hippocampus, septal area and frontal cortex were depressed significantly throughout the 60 min postinjection period. HYpothalamic and parietal flows were depressed at 10 and 30 min, but recovered by 60 min, whereas flow to the cerebellum was depressed between 30 and 60 min postinjection. The least changed and therefore relatively better perfused area throughout the first 60 min period was the occipital cortex. By contrast, at 24 hr, when perfusion of all brain regions had returned to near control levels, flow to the occipital cortex was elevated. During the first hour after treatment with either ORG-2766 or alphaMSH the patterns of regional circulation in the brain were qualitatively the same. The data suggest that ORG-2766 and, probably, alpha MSH trigger serially linked neurophysiologic changes in the brain lasting at least 24 hr, which organize the behavioral actions of this class of peptides on memory and attentional processes.
在静脉注射一种强效的、具有行为活性的促肾上腺皮质激素/促黑素4-9类似物（ORG-2766）后，对清醒雄性大鼠在10分钟、30分钟、60分钟和24小时时测量其局部脑血流量（rCBF）。在注射后的60分钟内，基底神经节、海马体、隔区和额叶皮质的血流量显著降低。下丘脑和顶叶的血流量在10分钟和30分钟时降低，但在60分钟时恢复，而小脑的血流量在注射后30至60分钟时降低。在最初的60分钟内变化最小且因此灌注相对较好的区域是枕叶皮质。相比之下，在24小时时，当所有脑区的灌注已恢复到接近对照水平时，枕叶皮质的血流量升高。在用ORG-2766或α-促黑素治疗后的第一小时内，脑内局部循环模式在性质上是相同的。数据表明，ORG-2766以及可能的α-促黑素触发了大脑中一系列相互关联的神经生理变化，这些变化至少持续24小时，从而组织了这类肽对记忆和注意力过程的行为作用。
