Goldman H, Sandman C A, Kastin A J, Murphy S
Pharmacol Biochem Behav. 1975 Jul-Aug;3(4):661-4. doi: 10.1016/0091-3057(75)90188-4.
With the single exception of the occipital cortex, the flow of blood to most regions of the brains of conscious, unrestrained rats was reduced within 10 min after intravenous administration of alphaMSH. Though these effects were transitory for most regions of the brain, perfusion of cerebellum, pons and medulla, hippocampus, and parietal cortex was still significantly low by 20 min. Assuming that flow changes reflect functional changes, these early responses to alphaMSH suggest an explanation for the effects of this hormone in which visual learning is improved.
除枕叶皮质外,在对清醒、未受束缚的大鼠静脉注射α-促黑素(alphaMSH)后10分钟内,其大脑大多数区域的血流减少。尽管这些影响对大脑的大多数区域来说是暂时的,但到20分钟时,小脑、脑桥、延髓、海马体和顶叶皮质的灌注仍显著偏低。假设血流变化反映功能变化,那么对α-促黑素的这些早期反应为该激素改善视觉学习的作用提供了一种解释。