Dunn A J, Hurd R W
Brain Res Bull. 1984 Apr;12(4):369-71. doi: 10.1016/0361-9230(84)90106-0.
Mice were treated with [MET(O2)4, D-Lys8,Phe9]ACTH4-9 (ORG 2766, 100 micrograms/kg per day SC) for 10 days. On the tenth day mice were injected with [3H]2-deoxyglucose and its cerebral accumulation determined in 17 brain areas. The combined results of four experiments indicated a significant decrease of the 2-deoxyglucose accumulation in the septum. Changes observed in other brain areas were not statistically significant in the combined analysis of all four experiments. This selective change in the septum is consistent with selective uptake of ORG 2766 in this region, and with the lack of behavioral activity of ACTH in septal lesioned animals. It also suggests that the behavioral activity of this peptide, generally considered to be on arousal, vigilance, and/or selective attention, may be mediated through the septum, a limbic system structure.
小鼠每日皮下注射[MET(O2)4, D-Lys8,Phe9]促肾上腺皮质激素4-9（ORG 2766，100微克/千克），持续10天。在第10天，给小鼠注射[3H]2-脱氧葡萄糖，并测定其在17个脑区的脑内蓄积量。四项实验的综合结果表明，隔区的2-脱氧葡萄糖蓄积量显著降低。在所有四项实验的综合分析中，其他脑区观察到的变化无统计学意义。隔区的这种选择性变化与ORG 2766在该区域的选择性摄取一致，也与促肾上腺皮质激素在隔区损伤动物中缺乏行为活性一致。这还表明，通常认为该肽在唤醒、警觉和/或选择性注意方面的行为活性可能是通过隔区介导的，隔区是边缘系统的一个结构。
