Key Laboratory of Gene Engineering of the Ministry of Education, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, PR China.
Int Immunopharmacol. 2012 Jul;13(3):301-7. doi: 10.1016/j.intimp.2012.04.019. Epub 2012 May 7.
Naringin is a flavanone with various bioactivities including expectorant effect, antitussive effect and inhibitory effects on asthma and acute lung injury. In present study we examined the effects of naringin on enhanced cough, airway hyperresponsiveness (AHR) and airway inflammation in chronic cigarette smoke (CS) exposure-induced chronic bronchitis in guinea pigs. To achieve this, guinea pigs were exposed to CS for 8weeks (10cigarettes/day, 6days/week). Oral administration of naringin (9.2, 18.4 and 36.8mg/kg) significantly attenuated the enhanced cough and AHR in smoke-exposed guinea pigs, reduced the concentrations of interleukin-8 (IL-8), leukotriene B4 (LTB4) and tumor necrosis factor-α (TNF-α) in bronchoalveolar lavage fluid (BALF) and decreased the myeloperoxidase (MPO) activity in both BALF and lung tissue, but did not significantly decrease the leukocytes in BALF. Naringin also improved superoxidase dismutase (SOD) activity in lung tissue and increased the content of lipoxin A4 (LXA4) in BALF in this guinea pig model of chronic bronchitis. These results suggested that naringin exhibited antitussive, anti-AHR and anti-inflammation effects on chronic CS exposure-induced chronic bronchitis in guinea pigs, and may possess novel therapeutic potential in the treatment of chronic bronchitis.
柚皮苷是一种具有多种生物活性的类黄酮，包括祛痰作用、镇咳作用以及对哮喘和急性肺损伤的抑制作用。在本研究中，我们研究了柚皮苷对慢性香烟烟雾（CS）暴露诱导的豚鼠慢性支气管炎增强性咳嗽、气道高反应性（AHR）和气道炎症的影响。为此，豚鼠接受 CS 暴露 8 周（每天 10 支香烟，每周 6 天）。柚皮苷（9.2、18.4 和 36.8mg/kg）口服给药可显著减轻烟雾暴露豚鼠的增强性咳嗽和 AHR，降低支气管肺泡灌洗液（BALF）中白细胞介素-8（IL-8）、白三烯 B4（LTB4）和肿瘤坏死因子-α（TNF-α）的浓度，并降低 BALF 和肺组织中的髓过氧化物酶（MPO）活性，但对 BALF 中的白细胞无明显减少作用。柚皮苷还可改善肺组织中超氧化物歧化酶（SOD）活性，并增加慢性支气管炎豚鼠模型 BALF 中的脂氧素 A4（LXA4）含量。这些结果表明，柚皮苷对慢性 CS 暴露诱导的慢性支气管炎豚鼠具有镇咳、抗 AHR 和抗炎作用，可能在慢性支气管炎的治疗中具有新的治疗潜力。
