Alam Mahboob, Ahsan Farogh, Mahmood Tarique, Shamim Arshiya, Parveen Saba, Shariq Mohammad, Ansari Vaseem Ahmad
Department of Pharmacy, Faculty of Pharmacy, Integral University, Kursi Road, Lucknow, India.
Avicenna J Phytomed. 2022 Sep-Oct;12(5):457-474. doi: 10.22038/AJP.2022.20001.
Medicinal plants having antioxidant potential possess numerous constituents which are responsible for different beneficial effects and are used as an alternative resource of medicine to lessen diseases linked with oxidative stress. Flavonoids are identified in the plants since ages and display wide spectrum of biological actions that might be able to stimulate the steps which are disturbed in different diseases. Flavonoids are significant natural compounds with various biologic properties, among which the most common is the anti-oxidant potential. Citrus flavonoids establish an important stream of flavonoids. Naringin, very common flavonoids present in the diet, belongs to the family of flavanone. It is the principal constituent of citrus family that contains flavonoids for example tomatoes, grapefruits and oranges.
In this article, we reviewed naringin with respect to sources, chemical property, pharmacokinetics, pharmacological activity, and novel formulations. The literature survey has been done by searching different databases such as Psyc INFO, Science Direct, PubMed, EMBASE, Google, Google Scholar, Medline.
Naringin is known to behave as an antioxidant and possess anti-inflammatory, anti-apoptotic, anti-atherosclerotic, neuroprotective, anti-psychotic, anti-asthmatic, anti-diabetic, hepatoprotective, anti-tussive, cardioprotective, and anti-obesity activity. Further clinical studies using large sample sizes remain essential to obtain the appropriate dose and form of naringin for averting diseases. Furthermore, the therapeutic approach of these bioflavonoids is significantly inappropriate due to the lack of clinical evidence. Different plants must be explored further to find these bioflavonoids in them.
The results of this exploration provides biological actions of bioflavonoid (naringin), predominantly on pharmacological and novel dosage forms of naringin.
具有抗氧化潜力的药用植物含有多种成分，这些成分具有不同的有益作用，可作为药物的替代资源，以减轻与氧化应激相关的疾病。黄酮类化合物自古以来就在植物中被发现，具有广泛的生物活性，可能能够刺激在不同疾病中受到干扰的生理过程。黄酮类化合物是具有多种生物学特性的重要天然化合物，其中最常见的是抗氧化潜力。柑橘类黄酮是黄酮类化合物的一个重要分支。柚皮苷是饮食中非常常见的黄酮类化合物，属于黄烷酮家族。它是柑橘类家族的主要成分，柑橘类家族还包括含有黄酮类化合物的番茄、葡萄柚和橙子。
在本文中，我们综述了柚皮苷的来源、化学性质、药代动力学、药理活性和新型制剂。通过搜索不同的数据库，如Psyc INFO、Science Direct、PubMed、EMBASE、谷歌、谷歌学术、Medline进行文献调研。
已知柚皮苷具有抗氧化作用，并具有抗炎、抗凋亡、抗动脉粥样硬化、神经保护、抗精神病、抗哮喘、抗糖尿病、肝保护、止咳、心脏保护和抗肥胖活性。进一步使用大样本量的临床研究对于确定预防疾病所需的柚皮苷合适剂量和剂型仍然至关重要。此外，由于缺乏临床证据，这些生物黄酮类化合物的治疗方法明显不合适。必须进一步探索不同的植物以从中发现这些生物黄酮类化合物。
本探索结果提供了生物黄酮类化合物（柚皮苷）的生物学作用，主要是关于柚皮苷的药理学和新型剂型。
