Department of Microbiology, School of Medicine, University of Patras, 26500 Patras, Greece.
Mycopathologia. 2012 Oct;174(4):301-9. doi: 10.1007/s11046-012-9552-9. Epub 2012 May 11.
Rhodotorula species are commensal yeasts that have emerged as a cause of life-threatening fungemia in severely immunocompromised patients. A case of Rhodotorula mucilaginosa fungemia in a 48-year-old woman that had undergone consecutive abdominal surgeries due to ovarian cancer and bowel necrosis while she was receiving fluconazole prophylaxis is presented. Several risk factors were identified such as presence of central venous catheters, solid organ neoplasm, abdominal surgery and administration of antibiotics. Identification was performed using commercial systems. The yeast was resistant to fluconazole, posaconazole and voriconazole and to echinocandins, whereas MIC to amphotericin B was 1.5 mg/L. Furthermore, published cases of Rhodotorula spp fungemia during the last decade are reviewed. In conclusion, Rhodotorula spp must be considered a potential pathogen in patients with immunosupression and central venous catheters. Correct identification is mandatory for appropriate management, as Rhodotorula spp are resistant to antifungal agents, such as fluconazole and echinocandins.
红酵母属是共生酵母，已成为严重免疫功能低下患者发生危及生命的真菌血症的原因。本文报道了一例氟康唑预防治疗期间因卵巢癌和肠坏死而连续接受腹部手术的 48 岁女性感染粘红酵母真菌血症的病例。确定了多个危险因素，如中央静脉导管、实体器官肿瘤、腹部手术和抗生素的使用。鉴定是使用商业系统进行的。该酵母对氟康唑、泊沙康唑和伏立康唑以及棘白菌素类药物具有耐药性，而两性霉素 B 的 MIC 为 1.5mg/L。此外，还回顾了过去十年中发表的关于红酵母属菌血症的病例。总之，在免疫抑制和中央静脉导管患者中，应将红酵母属视为一种潜在的病原体。正确的鉴定对于适当的管理是强制性的，因为红酵母属对氟康唑和棘白菌素类等抗真菌药物具有耐药性。
