Schneider A, Albertsmeier M, Böttiger B W, Teschendorf P
Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Köln, Kerpener Str. 62, 50937 Köln, Deutschland.
Anaesthesist. 2012 May;61(5):424-36. doi: 10.1007/s00101-012-2002-8.
Cardiac arrest with subsequent cardiopulmonary resuscitation causes an ischemic reperfusion syndrome of the whole body resulting in localized damage of particularly sensitive organs, such as the brain and heart, together with systemic sequelae. The main factor is a generalized activation of inflammatory reactions resulting in symptoms similar in many aspects to those of sepsis. Systemic inflammation strengthens organ damage due to disorders in the macrocirculation and microcirculation due to metabolic imbalance as well as the effects of direct leukocyte transmitted tissue destruction. The current article gives an overview on the role of inflammation following cardiac arrest and presents in detail the underlying mechanisms, the clinical symptoms and possible therapeutic approaches.
心脏骤停后进行心肺复苏会引发全身缺血再灌注综合征，导致特别敏感的器官如脑和心脏出现局部损伤，并伴有全身后遗症。主要因素是炎症反应的全身性激活，导致在许多方面与脓毒症相似的症状。全身炎症会因代谢失衡导致的大循环和微循环紊乱以及白细胞直接介导的组织破坏作用而加重器官损伤。本文概述了心脏骤停后炎症的作用，并详细介绍了其潜在机制、临床症状和可能的治疗方法。
