Institute of Biophysics, Academy of Sciences of the Czech Republic, vvi, Brno, Czech Republic.
Oxid Med Cell Longev. 2012;2012:181295. doi: 10.1155/2012/181295. Epub 2012 Apr 23.
Neutrophils represent the front-line defence cells in protecting organisms against infection and play an irreplaceable role in the proper performance of the immune system. As early as within the first minutes of stimulation, neutrophilic NADPH oxidase is activated, and cells release large quantities of highly toxic reactive oxygen species (ROS). These oxidants can be highly toxic not only for infectious agents but also for neighboring host tissues. Since flavonoids exhibit antioxidant and anti-inflammatory effects, they are subjects of interest for pharmacological modulation of ROS production. The present paper summarizes contemporary knowledge on the effects of various flavonoids on the respiratory burst of mammalian neutrophils. It can be summarized that the inhibitory effects of flavonoids on the respiratory burst of phagocytes are mediated via inhibition of enzymes involved in cell signaling as well as via modulation of redox status. However, the effects of flavonoids are even more complex, and several sites of action, depending upon the flavonoid structure and way of application, are included.
中性粒细胞是保护机体免受感染的一线防御细胞，在免疫系统的正常功能中发挥着不可替代的作用。早在受到刺激后的最初几分钟内，中性粒细胞 NADPH 氧化酶就被激活，细胞会释放大量的高毒性活性氧（ROS）。这些氧化剂不仅对感染因子具有高度毒性，而且对邻近的宿主组织也具有毒性。由于类黄酮具有抗氧化和抗炎作用，因此它们是调节 ROS 产生的药理学调制的研究对象。本文总结了关于各种类黄酮对哺乳动物中性粒细胞呼吸爆发的影响的最新知识。可以总结出，类黄酮对吞噬细胞呼吸爆发的抑制作用是通过抑制参与细胞信号转导的酶以及通过调节氧化还原状态来介导的。但是，类黄酮的作用甚至更加复杂，并且根据类黄酮的结构和应用方式，包含了几个作用部位。
