Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
Trends Immunol. 2012 Jun;33(6):289-96. doi: 10.1016/j.it.2012.04.004. Epub 2012 May 10.
Gut-associated lymphoid tissue (GALT) is a sensor region for luminal content and plays an important role in lymphoid maturation, activation and differentiation. It comprises isolated and aggregated lymphoid follicles, cryptopatches (CPs) and tertiary lymphoid tissue. Innate lymphoid cells (ILCs) play a central role within GALT. Prenatal GALT development is dependent on ILC lymphoid-inducer function. Postnatally, these cells rapidly respond to commensal and pathogenic intestinal bacteria, parasites and food components by polarized cytokine production [such as interleukin (IL)-22, IL-17 or IL-13] and further contribute to GALT formation and function. Here, we discuss how ILCs shape lymphoid intestinal microenvironments and act as amplifier cells for innate and adaptive immune responses.
肠相关淋巴组织 (GALT) 是腔内容物的感应区域，在淋巴成熟、激活和分化中发挥重要作用。它包括孤立和聚集的淋巴滤泡、隐窝（CP）和三级淋巴组织。先天淋巴细胞 (ILC) 在 GALT 中发挥核心作用。产前 GALT 发育依赖于 ILC 淋巴诱导功能。出生后，这些细胞通过极化细胞因子产生（如白细胞介素 (IL)-22、IL-17 或 IL-13），快速响应共生菌和病原菌、寄生虫和食物成分，进一步促进 GALT 的形成和功能。在这里，我们讨论了 ILC 如何塑造肠内淋巴微环境，并作为先天和适应性免疫反应的放大器细胞。
