Fallon B A, Liebowitz M R, Hollander E, Schneier F R, Campeas R B, Fairbanks J, Papp L A, Hatterer J A, Sandberg D
NYS Psychiatric Institute, NY 10032.
J Clin Psychiatry. 1990 Dec;51(12):517-21.
Moral or religious scrupulosity is a disabling condition which is sometimes seen in patients with obsessive compulsive disorder (OCD). The authors described 10 patients with moral or religious scrupulosity who were treated with fluoxetine or clomipramine. Seven of the 10 patients completed open treatment of at least 8 weeks without requiring adjunctive medication; 5 of those 7 patients were rated as much improved. Among the 3 patients who required adjunctive medication, 1 was rated as much improved. Of the 4 nonresponders at 3 months, 2 responded after longer treatment trials. These results suggest that extreme moral or religious concerns and behaviors might be a form of OCD and that the scrupulosity can be effectively treated with serotonin reuptake blockers.
道德或宗教洁癖是一种致残性病症，有时见于强迫症（OCD）患者。作者描述了10例患有道德或宗教洁癖的患者，他们接受了氟西汀或氯米帕明治疗。10例患者中有7例完成了至少8周的开放治疗，无需辅助用药；这7例患者中有5例被评定为明显改善。在3例需要辅助用药的患者中，1例被评定为明显改善。在3个月时无反应的4例患者中，2例在更长疗程的治疗试验后有反应。这些结果表明，极端的道德或宗教担忧及行为可能是强迫症的一种形式，且洁癖可用5-羟色胺再摄取阻滞剂有效治疗。
