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[血浆脂蛋白与载脂蛋白]

[Plasma lipoproteins and apolipoproteins].

作者信息

Reuter W

出版信息

Z Gesamte Inn Med. 1979 May 1;34(9):241-6.

PMID:225895
Abstract

In a survey the plasmalipoproteins LDL, VLDL and HDL are characterized and their functions demonstrated. Metabolically they are connected together through the IDL. Their clinical importance lies in the disturbances of the lipoprotein metabolism, which are significant for hyperlipoproteinaemia and arteriosclerotic diseases. Atypical plasmalipoproteins are LP(a), pre-beta-1-lipoprotein and sinking-pre-beta-lipoproteins. The LP-X is of interest for the differential diagnosis of jaundice. The carrier proteins of the plasmalipoproteins, the apolipoproteins, are Apo A, Apo B, Apo C, Apo D, and Apo E. They are differently structured. Their concentration in the individual plasmalipoproteins are also responsible for their function in normal and pathological lipid metabolism.

摘要

在一项调查中,对血浆脂蛋白低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)和高密度脂蛋白(HDL)进行了表征,并展示了它们的功能。在代谢方面,它们通过中间密度脂蛋白(IDL)相互联系。它们的临床重要性在于脂蛋白代谢紊乱,这对高脂蛋白血症和动脉粥样硬化疾病具有重要意义。非典型血浆脂蛋白有脂蛋白(a)[LP(a)]、前β-1-脂蛋白和下沉前β-脂蛋白。LP-X对黄疸的鉴别诊断具有重要意义。血浆脂蛋白的载体蛋白即载脂蛋白有载脂蛋白A(Apo A)、载脂蛋白B(Apo B)、载脂蛋白C(Apo C)、载脂蛋白D(Apo D)和载脂蛋白E(Apo E)。它们的结构各不相同。它们在各个血浆脂蛋白中的浓度也决定了它们在正常和病理脂质代谢中的功能。

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