Onuma T
National Center Hospital for Mental, Nervous and Muscular Disease, NCNP, Kodaira, Japan.
Jpn J Psychiatry Neurol. 1990 Jun;44(2):283-8. doi: 10.1111/j.1440-1819.1990.tb01407.x.
A total of 28 cases of severely deteriorated epileptic patients were seen at out- and inpatient services in the past 12 years. In 22 out of these 28 cases, the etiology for the deterioration was considered to be due to either repetitive intractable seizures or antiepileptic drugs (AEDs) or both. Although differential diagnoses were difficult in many cases as to the responsible causes, namely seizure vs. AEDs, it was considered in 6 cases that AEDs took a major role in their deterioration. Details of such cases are presented. Special emphasis was made to the fact in which they frequently showed episodes of acute or ataxia and confusion often associated with febrile illness. They took a course of acute or subacute exacerbation and partial remission. Discussion was held on the nature and possible avoidance of these deteriorations.
在过去12年里，门诊和住院部共接诊了28例癫痫病情严重恶化的患者。在这28例患者中，有22例病情恶化的病因被认为是反复难治性癫痫发作、抗癫痫药物（AEDs）或两者兼而有之。尽管在许多情况下，很难区分癫痫发作和AEDs哪个是导致病情恶化的主要原因，但有6例被认为AEDs在病情恶化中起主要作用。本文介绍了这些病例的详细情况。特别强调的是，这些患者经常出现急性发作或共济失调以及与发热性疾病相关的意识模糊。他们经历了急性或亚急性加重以及部分缓解的过程。本文还对这些病情恶化的性质及可能的预防措施进行了讨论。
