National Institute of Chemistry, Ljubljana, Slovenia.
Nucleic Acids Res. 2012 Jul;40(Web Server issue):W214-21. doi: 10.1093/nar/gks435. Epub 2012 May 16.
The ProBiS web server is a web server for detection of structurally similar binding sites in the PDB and for local pairwise alignment of protein structures. In this article, we present a new version of the ProBiS web server that is 10 times faster than earlier versions, due to the efficient parallelization of the ProBiS algorithm, which now allows significantly faster comparison of a protein query against the PDB and reduces the calculation time for scanning the entire PDB from hours to minutes. It also features new web services, and an improved user interface. In addition, the new web server is united with the ProBiS-Database and thus provides instant access to pre-calculated protein similarity profiles for over 29 000 non-redundant protein structures. The ProBiS web server is particularly adept at detection of secondary binding sites in proteins. It is freely available at http://probis.cmm.ki.si/old-version, and the new ProBiS web server is at http://probis.cmm.ki.si.
ProBiS 网络服务器是一个用于在 PDB 中检测结构相似的结合位点以及进行蛋白质结构局部两两比对的网络服务器。在本文中，我们介绍了 ProBiS 网络服务器的新版本，由于 ProBiS 算法的高效并行化，它的速度比以前的版本快 10 倍，现在可以显著加快蛋白质查询与 PDB 的比较速度，并将扫描整个 PDB 的计算时间从数小时缩短到数分钟。它还具有新的网络服务和改进的用户界面。此外，新的网络服务器与 ProBiS-Database 联合，因此可以即时访问超过 29000 个非冗余蛋白质结构的预计算蛋白质相似性概况。ProBiS 网络服务器特别擅长于检测蛋白质中的次要结合位点。它可免费在 http://probis.cmm.ki.si/old-version 获得，而新的 ProBiS 网络服务器则在 http://probis.cmm.ki.si。
