Müller O, Moser R
League of Red Cross and Red Crescent Societies, Geneva, Switzerland.
Trans R Soc Trop Med Hyg. 1990 May-Jun;84(3):336-8. doi: 10.1016/0035-9203(90)90306-y.
The relation between Plasmodium falciparum malaria and symptomatic human immunodeficiency virus 1 (HIV-1) infection was investigated in paediatric and adult patients in Kampala, Uganda, from 1987 to 1989. Both infections contributed largely to hospital morbidity. Of 1527 clinically suspicious in-patients, 61% were positive for HIV-1 infection. 52% of patients with positive HIV-1 serology fulfilled the World Health Organization clinical case definition for acquired immune deficiency syndrome (AIDS) in Africa. No association could be found between HIV-1 infection and malaria either in paediatrics or in adults. P. falciparum parasitaemia was present in 18% of all patients and no differences in prevalence of malaria infection or in parasite density could be demonstrated between HIV-1 positive and HIV-1 negative patients. The comparison of clinical symptoms showed typical differences in AIDS-related morbidity but no difference in malaria-specific morbidity. Also, the response to malaria treatment was the same in HIV-1 positive and HIV-1 negative patients. P. falciparum malaria does not appear to act as an opportunistic agent in AIDS patients in Uganda.
1987年至1989年期间，在乌干达坎帕拉的儿科和成年患者中研究了恶性疟原虫疟疾与有症状的人类免疫缺陷病毒1型（HIV-1）感染之间的关系。这两种感染在很大程度上导致了医院的发病率。在1527名临床疑似住院患者中，61%的患者HIV-1感染呈阳性。HIV-1血清学检测呈阳性的患者中，52%符合世界卫生组织关于非洲获得性免疫缺陷综合征（AIDS）的临床病例定义。在儿科患者或成年患者中，均未发现HIV-1感染与疟疾之间存在关联。所有患者中有18%存在恶性疟原虫血症，HIV-1阳性和HIV-1阴性患者之间在疟疾感染患病率或寄生虫密度方面未显示出差异。临床症状比较显示，与艾滋病相关的发病率存在典型差异，但疟疾特异性发病率无差异。此外，HIV-1阳性和HIV-1阴性患者对疟疾治疗的反应相同。在乌干达，恶性疟原虫疟疾似乎不会在艾滋病患者中作为机会性病原体起作用。
