Ebmeier K P, Potter D D, Cochrane R H, Mackenzie A R, MacAllister H, Besson J A, Salzen E A
Department of Mental Health, University of Aberdeen, United Kingdom.
Acta Psychiatr Scand. 1990 Oct;82(4):283-8. doi: 10.1111/j.1600-0447.1990.tb01385.x.
Twenty-five DSM-III-diagnosed schizophrenics and 37 normal and age-matched controls were examined using an oddball paradigm for the generation of P300 and smooth eye-pursuit tasks. Results were compared between groups and related to clinical characteristics, including a family history of psychiatric illness. Group differences were found for P300 amplitudes, latencies and eye-tracking. A family history of psychiatric illness was associated with normal eye-tracking in patients. Small P300 amplitudes alone and in combination with long P300 latencies were associated with a family history in controls.
使用奇偶数范式对25名经《精神疾病诊断与统计手册》第三版（DSM-III）诊断的精神分裂症患者以及37名年龄匹配的正常对照者进行了检查，以记录P300和眼球平稳跟踪任务。对两组结果进行了比较，并与包括精神疾病家族史在内的临床特征相关联。发现两组在P300波幅、潜伏期和眼动跟踪方面存在差异。精神疾病家族史与患者正常的眼动跟踪相关。单独的小P300波幅以及与长P300潜伏期相结合与对照组的家族史相关。
