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通过硅胶硫酸催化腈与叠氮化钠的[3+2]环加成反应改进5-取代-1H-四唑的合成。

Improved synthesis of 5-substituted 1H-tetrazoles via the [3+2] cycloaddition of nitriles and sodium azide catalyzed by silica sulfuric acid.

作者信息

Du Zhenting, Si Changmei, Li Youqiang, Wang Yin, Lu Jing

机构信息

College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.

Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Talimu University, Alaer, Xinjiang 843300, China.

出版信息

Int J Mol Sci. 2012;13(4):4696-4703. doi: 10.3390/ijms13044696. Epub 2012 Apr 12.

DOI:10.3390/ijms13044696
PMID:22606004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3344240/
Abstract

A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%-95% yield.

摘要

描述了一种二氧化硅负载硫酸催化腈与叠氮化钠的[3+2]环加成反应以形成5-取代的1H-四唑。该方法可以使用二氧化硅硫酸，以72%-95%的产率，在DMF中由腈和叠氮化钠制备一系列5-取代的1H-四唑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b7/3344240/7538d0a36196/ijms-13-04696f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b7/3344240/7538d0a36196/ijms-13-04696f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b7/3344240/7538d0a36196/ijms-13-04696f1.jpg

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