血管紧张素转换酶I/D多态性是糖尿病周围神经病变的一种遗传生物标志物：一项荟萃分析的证据。
Angiotensin-converting enzyme I/D polymorphism is a genetic biomarker of diabetic peripheral neuropathy: evidence from a meta-analysis.
作者信息
Xu Weiguo, Qian Yunfeng, Zhao Luqian
机构信息
Department of Geriatrics, Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010, Guangdong, China.
Department of Gerontology Endocrinology, Guangzhou First Municipal Hospital Guangzhou 510180, Guangdong, China.
出版信息
Int J Clin Exp Med. 2015 Jan 15;8(1):944-8. eCollection 2015.
The Angiotensin-converting enzyme (ACE) I/D polymorphism has been indicated to be correlated with peripheral neuropathy (PN) susceptibility, but study results are still debatable. Thus, a meta-analysis was conducted. Databases including PubMed, Embase and CNKI were searched. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Eight studies with 1430 cases and 1873 controls were included in this meta-analysis. The association between ACE I/D polymorphism and PN risk was significant (OR = 1.25; 95% CI 1.05-1.48; P = 0.01). When stratified by ethnicity, the significantly increased PN risk was observed in Caucasians (OR = 1.24; 95% CI 1.05-1.47; P = 0.01). In conclusion, this meta-analysis suggested that ACE I/D polymorphism was a risk factor for PN.
血管紧张素转换酶（ACE）I/D多态性已被表明与周围神经病变（PN）易感性相关，但研究结果仍存在争议。因此，进行了一项荟萃分析。检索了包括PubMed、Embase和中国知网在内的数据库。提取数据并计算合并比值比（OR）及95%置信区间（CI）。本荟萃分析纳入了8项研究，共1430例病例和1873例对照。ACE I/D多态性与PN风险之间的关联具有显著性（OR = 1.25；95% CI 1.05 - 1.48；P = 0.01）。按种族分层时，在白种人中观察到PN风险显著增加（OR = 1.24；95% CI 1.05 - 1.47；P = 0.01）。总之，本荟萃分析表明ACE I/D多态性是PN的一个危险因素。
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