Szmydynger-Chodobska J, Szczepańska-Sadowska E, Chodobski A
Department of Clinical and Applied Physiology, Institute of Physiological Sciences, School of Medicine, Warsaw, Poland.
Am J Physiol. 1990 Dec;259(6 Pt 2):R1250-8. doi: 10.1152/ajpregu.1990.259.6.R1250.
To find out whether central arginine vasopressin (AVP) plays a role in regulation of cerebrospinal fluid (CSF) composition and of CSF bulk flow (CSFbf) in acute hyperosmolar state, the experiments were performed on 16 anesthetized cats in which the ventriculocisternal system was perfused either with artificial CSF (aCSF; 8 control experiments) or with aCSF containing AVP (10 microU/min, 8 experiments) before, during, and after intravenous infusion of 5% NaCl. In both series, hyperosmotic infusion significantly increased CSF osmolality (CSFosmol) and sodium (CSFNa) and potassium (CSFK) concentration and reduced CSFbf. Administration of AVP significantly influenced the dynamics of changes in CSFNa and slightly affected changes in CSFK concentration induced by infusion of hyperosmotic saline, while it did not modify changes in CSFosmol) and CSFbf. In control experiments, CSFbf was significantly related to plasma and CSF osmolalities and sodium concentrations, whereas in AVP experiments these relationships were markedly suppressed. The results suggest that during acute hyperosmolar state AVP significantly influences sodium handling in CSF and may play a role in adaptation of the brain to hyperosmolality.
为了探究在急性高渗状态下，中枢精氨酸加压素（AVP）是否在脑脊液（CSF）成分调节及脑脊液总体流量（CSFbf）调节中发挥作用，对16只麻醉猫进行了实验。在静脉输注5%氯化钠之前、期间及之后，通过脑室池系统分别灌注人工脑脊液（aCSF；8次对照实验）或含AVP的aCSF（10微单位/分钟，8次实验）。在两个系列实验中，高渗输注均显著提高了脑脊液渗透压（CSFosmol）、钠（CSFNa）和钾（CSFK）浓度，并降低了CSFbf。给予AVP显著影响了CSFNa的变化动态，并轻微影响了高渗盐水输注引起的CSFK浓度变化，而对CSFosmol和CSFbf的变化无影响。在对照实验中，CSFbf与血浆及脑脊液渗透压和钠浓度显著相关，而在AVP实验中，这些关系明显受到抑制。结果表明，在急性高渗状态下，AVP显著影响脑脊液中钠的处理，可能在大脑适应高渗状态中发挥作用。
