Rosenberg G A, Robertson G L
Neurosci Lett. 1987 Mar 20;75(1):60-4. doi: 10.1016/0304-3940(87)90075-9.
Arginine-vasopressin (AVP) has been found to influence brain water. Since AVP is released by hyperosmolality into plasma we determined the role of AVP in controlling cerebrospinal fluid (CSF) pressure. Adult cats were anesthetized with pentobarbital and samples of plasma and cisternal CSF were collected 1 or 2 h before i.v. infusion of 2 g/kg of mannitol and for 2 h afterwards. We found a significant increase in plasma osmolality from 320.0 +/- 1.6 to 331.6 +/- -3.4 mOsm/l (mean +/- S.E.M.), while CSF osmolality was unchanged. Prior to mannitol infusion, AVP was elevated to 105 +/- 19 pg/ml in plasma and to 136 +/- 19 pg/ml (mean +/- S.E.M.) in CSF. After infusion of mannitol AVP levels were unchanged in either plasma or CSF. The reduction of CSF pressure by mannitol is independent of AVP in the anesthetized cat.
精氨酸加压素（AVP）已被发现会影响脑内水分。由于高渗状态会促使AVP释放进入血浆，我们研究了AVP在控制脑脊液（CSF）压力方面的作用。成年猫用戊巴比妥麻醉，在静脉输注2 g/kg甘露醇前1或2小时以及之后2小时采集血浆和脑池CSF样本。我们发现血浆渗透压从320.0±1.6显著升高至331.6±3.4 mOsm/l（均值±标准误），而CSF渗透压未变。在输注甘露醇前，血浆中AVP升高至105±19 pg/ml，CSF中升高至136±19 pg/ml（均值±标准误）。输注甘露醇后，血浆或CSF中的AVP水平均未改变。在麻醉猫中，甘露醇降低CSF压力与AVP无关。
