Harding Scott V, Rideout Todd C, Jones Peter J H
Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, 150 Stamford Street, London, UK.
J Diet Suppl. 2012 Jun;9(2):116-27. doi: 10.3109/19390211.2012.683136.
Alpha lipoic acid (α-LA) is a potent biological antioxidant that is found naturally in the human body at very low concentrations, primarily in the mitochondria. However, synthetic α-LA is commercially available as a nutritional supplement and has been shown to be effective at ameliorating symptoms in diseases with an underlying oxidative stress component. High blood cholesterol is a major cardiovascular disease (CVD) risk factor and is responsive to diet and lifestyle modifications. In addition to high blood cholesterol, there is increasing evidence that supports the independent role of oxidized lipids and lipoproteins, chiefly oxidized low-density lipoproteins (Ox-LDL), in the development of CVD. Lowering total blood cholesterol (TC), LDL cholesterol (LDL-C), and triglycerides (TG) and raising high-density lipoprotein cholesterol (HDL-C) levels is the most desirable metabolic state for maximum protection against CVD, but can be difficult to achieve through diet and exercise alone. With emerging evidence of reduced LDL-C and TG, increased HDL-C, and blunting of oxidative susceptibility of lipoproteins by α-LA, its use alone or in combination with other dietary supplements may be an effective strategy to modulate multiple metabolic targets of oxidative stress and cholesterol metabolism to reduce CVD risk. This review examines the current evidence for the use of α-LA in CVD risk reduction and identifies the remaining gaps that must be addressed in this area of research.
α-硫辛酸（α-LA）是一种强效的生物抗氧化剂，在人体中天然存在，但浓度极低，主要存在于线粒体中。然而，合成的α-LA作为一种营养补充剂在市场上有售，并且已被证明在改善具有潜在氧化应激成分的疾病症状方面有效。高血胆固醇是主要的心血管疾病（CVD）危险因素，并且对饮食和生活方式的改变有反应。除了高血胆固醇外，越来越多的证据支持氧化脂质和脂蛋白，主要是氧化型低密度脂蛋白（Ox-LDL），在CVD发生中的独立作用。降低总血胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）以及提高高密度脂蛋白胆固醇（HDL-C）水平是预防CVD的最理想代谢状态，但仅通过饮食和运动可能难以实现。随着有新证据表明α-LA可降低LDL-C和TG、提高HDL-C以及减轻脂蛋白的氧化敏感性，单独使用α-LA或与其他膳食补充剂联合使用可能是调节氧化应激和胆固醇代谢的多个代谢靶点以降低CVD风险的有效策略。这篇综述考察了目前使用α-LA降低CVD风险的证据，并确定了该研究领域中仍需解决的空白。
